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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
E u r o p e a n C o n g r e s s o n
Vaccines & Vaccination
and Gynecologic Oncology
Vaccines & Vaccination and Gynecologic Oncology 2018
O c t o b e r 2 6 - 2 7 , 2 0 1 8
B u d a p e s t , H u n g a r y
F
used heterocyclic containing pyrazolopyridine systems have been described associated with several biological and medicinal
activities. So, in this study, we described firstly an expedient method for the synthesis of substituted pyrazolo [3,4-b]pyridines
derivatives in a single-step according to our recent study with synthesis strategy amelioration. Then, we screened for antibacterial
effects against respectively Bacteria (Escherichia coli CIP 53126 and
Bacillus subtilis
CIP 5262) and Fungi (
Candida albicans
ATCC
10231 and
Aspergillus Niger
ATCC 16404). Hence, according to the antimicrobial activity results, some of these compounds have
similar or higher activity compared with commercial antibiotic drugs (Spiramycin, Streptomycin and Fluconazol), which make
them suitable for diverse applications like the manufacturing of drugs, pesticides. In the other hand, their total inhibition against
Aspergillus Niger
provides evidence that these pyrazole formulations could be an alternative source for the treatment of fungal
infections caused by
Aspergillus Niger
ATCC 16404.
samarchtiba@yahoo.comTowards several biological activities compounds
S Chtiba
1,2
, H Tazarki
1,4
, I Amri
3,4
, J Khiari
1
and J Bassem
1
1
Institut Supérieur de l’Education et de la Formation Continue, Tunisia
2
Faculté des Sciences de Tunis (FST), Tunisia
3
Institut national de recherches en génie rural, Eaux et Forêts (INGREF), Tunisia
4
University of Carthage, Tunisia
Journal of Clinical Immunology and Allergy, Volume: 4
DOI: 10.21767/2471-304X-C2-006
Euro Vaccines 2018