vaccines-gynecologic-oncology-2018-posters

Page 97

Journal of Clinical Immunology and Allergy

ISSN: 2471-304X

E u r o p e a n C o n g r e s s o n

Vaccines & Vaccination

and Gynecologic Oncology

Vaccines & Vaccination and Gynecologic Oncology 2018

O c t o b e r 2 6 - 2 7 , 2 0 1 8

B u d a p e s t , H u n g a r y

everal problems were reported with conventional, sub-subunit, inactivated, recombinant and sub-mucosal vaccines.

Developing conventional vaccines is labour intensive, expensive and time-consuming. Identifying the most suitable antigens

to stimulate the immune system is the limitation with subunit vaccines. The inability to induce cellular immunity is the drawback

related to inactivated vaccines and recombinant vaccines. Identifying antibody response for gastric pathogen is the problem

with sub-mucosal vaccines. The problem interconnected with specificity of the vaccine is genetic diversity of the pathogen and

ethnicity of the patient’s population diversity. Therefore, identifying a suitable antigen as a vaccine candidate which can stimulate

the immune system, induce cellular immunity, sub-mucosal response against diverse pathogen and population is a challenging

task. In this connection, a novel immuno-informatics method is proposed against the above known problems by minimizing the

cost of both human and financial resources, without losing efficiency and time. The method includes retrieving the coding regions

of the genome and translating them to their respective proteome. Then, the proteome is screened for immuno-pathogenic factors

which are non-homologous, non-allergenic, and with helixes≤3. Further, epitopes which are conserved, non-homologous, elicit

both T-cell and B-cell response, interact with MHC alleles and IgA antibody, and elicit response in wide range of ethnic populations

are identified as suitable antigens. The above approach is a comprehensive immuno-informatics method that enables rapid

identification of sub mucosal vaccine candidates with immense potential for therapeutic intervention of pathogens.

A novel immunoinformatics method for screening

and identifying sub mucosal vaccine candidates

Neelapu N R R, Pasupuletti A M C, Challa S

Gandhi Institute of Technology and Management (GITAM), India

Journal of Clinical Immunology and Allergy, Volume: 4

DOI: 10.21767/2471-304X-C2-006

Euro Vaccines 2018