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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
E u r o p e a n C o n g r e s s o n
Vaccines & Vaccination
and Gynecologic Oncology
Vaccines & Vaccination and Gynecologic Oncology 2018
O c t o b e r 2 6 - 2 7 , 2 0 1 8
B u d a p e s t , H u n g a r y
Background:
Enteric fever has persistence of great impact in public health, it caused by
Salmonella
enterica
that seldom detected in
wastewaters of stabilization stations due to treatment processes
Objective:
The aim of this study is to evaluate the recent state of antibiotics susceptibility of
Salmonella
Typhi with special concern to
multidrug resistance strains and predict the emergence of new resistant patterns
Methods:
Salmonella
Typhi were isolated and identified according to WHO and ISO guidelines, the bacterial antibiotic susceptibilities
were tested using the CLSI recommendations. The predictions of resistance emergence were done using logistic regression, forecast-
ing linear equations and stochastic model.
Results:
A total of 128 antibiotics resistant
Salmonella
Typhi strain were recovered fromwastewater, they resisted antibiotics except ci-
profloxacin. Current patterns of ciprofloxacin breakpoints interpretations were in susceptible ranges by disc diffusion (S≥20 mm), mini-
mum inhibitory concentration was recorded as (I=16 µg/ml) and minimum bactericidal concentration= (R≥32 µg/ml). The probability of
an isolate to develop resistance was plotted for MBCs the rate of resistance. The predictive patterns of resistance were spontaneously
solved using exponential trend (y=ne ) for each isolate at 16 µg/ml and 32 µg/ml of ciprofloxacin in certain period and the high values
of coefficient R²>0.5 indicate the rates of bacteria resistance incidence.
Conclusions:
The current patterns of S. Typhi confirmed the increasing probability of emerging multidrug resistance according to fre-
quent consuming, drug policy and bacterium genetic mutations.
ayman_elshayeb@yahoo.comSystemic and predictive trends of multidrug
resistant Salmonella Typhi isolated from
wastewater in Sudan
Ayman Elshayeb
Sudan
Journal of Clinical Immunology and Allergy, Volume: 4
DOI: 10.21767/2471-304X-C2-006
Euro Vaccines 2018