vaccines-gynecologic-oncology-2018-posters

Page 73

Journal of Clinical Immunology and Allergy

ISSN: 2471-304X

E u r o p e a n C o n g r e s s o n

Vaccines & Vaccination

and Gynecologic Oncology

Vaccines & Vaccination and Gynecologic Oncology 2018

O c t o b e r 2 6 - 2 7 , 2 0 1 8

B u d a p e s t , H u n g a r y

Introduction:

There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uter-

ine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the

fetus. The current available technology doesn't allow observing what is happening at cellular level since the human brain is not exposed

to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia.

Methods:

In 1977, we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in

order to finding differences at cellular level in relation to controls.

Results:

In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles that

reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations.

Conclusion:

The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct

relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in women at risk of

having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the cells of

the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant, previous information of

the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later

development of the illness.

Direct evidence of viral infection and

mitochondrial alterations in the brain of fetuses

at high risk for schizophrenia

Segundo Mesa Castillo

Psychiatric Hospital of Havana, Cuba

Journal of Clinical Immunology and Allergy, Volume: 4

DOI: 10.21767/2471-304X-C2-006

Euro Vaccines 2018