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Preventive Medicine 2018 Journal of Preventive Medicine
ISSN: 2572-5483 Page 67
July 16-17, 2018
London, UK
9th Edition of International Conference on
Preventive Medicine
& Public Health
Lifestyle behaviors have been closely linked to the progressive
cell damage associated with oxidative stress (OS) and the
development of cardiovascular disease (CVD). Early detection of
lifestyle-linkedOSmaythereforebeusefulintheearlyidentification
of prodromal disease. To test this hypothesis, this study assessed
the relationship between a comprehensive redox balance lifestyle
score (RBLS) and carotid intima-media thickness (CIMT), a
recognized marker for CVD, and plasma biomarkers of OS. In a
cross-sectional study design, 100 apparently healthy middle-
aged participants were asked to complete a comprehensive
lifestyle questionnaire, followed by DXA scanning, CIMT
ultrasonography, and blood collection. The RBLS was composed
of lifestyle components with pro- and antioxidant properties with
a higher score indicative of lower oxidative activity. Multiple linear
regression and logistic regression analysis were performed for
statistical analysis. The RBLS was significantly associated with
the risk for increased CIMT that was independent of conventional
CVD risk factors ((χ2(9) = 35.60, P ≤ 0 001). The adjusted model
explained 42.4% of the variance in CIMT. Participants with
RBLS below the median were at significantly increased risk of
higher CIMT compared to participants with RBLS above the
median (OR=3.60, 95% CI: 1.19–10.88, P = 0.023). Significant
associations were also observed between the RBLS, plasma total
antioxidant capacity (TAC) (r: 99 = 0.28, P=0.006), hydroperoxide
(HPX) (rs: 99=−0.28, P=0.005), TAC/HPX ratio (r: 98 = 0.41, P ≤
0.001), ã-glutamyltransferase (r: 97=−0.23, P=0.024), uric acid
(r:98 = −0.20, P=0.045), and inflammatory C-reactive protein (rs:
97=−0.25, P=0.012) and interleukin-1â (r 97= −0.21, P=0.040).
These findings highlight the importance of identifying the
collective influence of lifestyle behaviors on OS activity and its
potential to remodel the vascular endothelium.
Evidence for a relationship between a composite lifestyle
score and risk of higher carotid intima- media thickness: Is
there a link to oxidative stress?
Neda Seyedsadjadi1, Jade Berg, Ayse A Bilgin and Ross Grant
1UNSW, Australia
J Prev Med 2018, Volume 3
DOI: 10.21767/2572-5483-C1-003