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American Journal of Ethnomedicine
ISSN: 2348-9502
April 16-17, 2018
Amsterdam, Netherlands
Pharmacognosy 2018
Page 42
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
M
ilitary personnel are often exposed to high summer heat
resulting in heat stroke (HS) resulting in serious mental
and physical consequences due to blood-brain barrier (BBB)
breakdown, edema formation and brain pathologies. In this
innovation, we used TiO
2
nanowired EGb-761 and BN-52021 to
treat HS induced brain pathologies in model experiments. Rats
were exposed to two hour HS daily for eight days in a biological
oxygen demand (BOD) incubator that does not induce brain
pathology. On the eighth day, the animals were subjected to a
four hour additional HS, and brain pathology was examined.
These animals exhibited profound BBB leakage to Evans
blue and [131]-Iodine, brain edema 2–4-fold higher neuronal
damages as compared sham treated naïve rats. Treatment
with EGb-761 (50 mg/kg, p.o.) with BN-52021 (2 mg/kg, p.o.)
daily, for five days reduced brain damage by 20 to 30% in HS.
However, when TiO
2
nanowired EGb-761 or TiO
2
BN-52021 were
administered in identical doses, more than 80% reduction in
brain pathology was observed in HS. The functional outcome
e.g., walking on a tilted mesh grid (45°C), staying on a Rota-Rod
treadmill (16 r.p.m.) and finding placing of forepaw on a wire
mesh were significantly improved by nanodelivery of EGb-761
and BN-52021. These observations suggest that nanodelivery
of EGb-761 and BN-52021 in HS has a potential therapeutic
value that requires further investigation.
Biography
Aruna Sharma is the Secretary of Research International Experimental
Central Nervous System (CNS) Injury & Repair (IECNSIR), currently work-
ing at Uppsala University Hospital, Uppsala University, Sweden. She is a
qualified Experimental Neurpathologist with training at Karl Marx Universi-
ty, Leipzig (1987-1988); Semmelweis University Medical School, Budapest
(1988-1989), Free University Berlin, (1989-1991) and Neuropathology In-
stitute Uppsala (1992-1995). She is focused on traditional Indian/Chinese
medicinal drugs on the central nervous system function, toxicology, neu-
rorepair and neuroprotection using nanotechnology. She earned the Top
15 Technology Award of 2016 at Global Innovation Summit & Showcase
on her recent innovation on, “Neuroprotective effects of Nanowired deliv-
ery of cerebrolysin together with alpha melanocyte stimulating hormone
(-MSH) in concussive head injury in sleep deprivation”, US Government,
Washington DC, May 22-25, 2016. She has published over 140 original re-
search papers in reputed neuroscience journals with an H-index of 19 (ISI
database, 143 citations) as of today.
Aruna.Sharma@surgsci.uu.seNanodelivery of Chinese traditional medicine
extract of Ginkgo biloba (EGb-761) induces
superior neuroprotection in heat stroke
Aruna Sharma
Uppsala University, Sweden
Aruna Sharma, Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-004