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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
RESULTS AND DISCUSSION
: Results are encouraging, as all other antibiotics were inactive against these strains. Methanolic
extract from
Cordia obliqua, Beautea monosperma and Cuminum cyminum possess
significant antimicrobial activity at very low
concentration (15µg/disc, 20µg/disc and 15µg/disc) on oral pathogenic bacteria. Qualitative chemical tests shown presence
of flavonoids, phenolics in the extracts, might be responsible for the activity. Formulated chewing gum has optimal hardness,
thickness and weight variation (in limit ±5%) as well as has pleasant appearance, fragrance, texture and taste is highly acceptable
by the volunteers, as compared to marketed formulation. The drug loading efficiency of the drug in chewing was found to be in
range of 98.2 ± 1.80% to 99.2 ± 0.35%. In all the cases, the R values of korsmayer papas model were close to 1. The diffusion
coefficient values ranged from 0.6655 to 0.9164. Since the R values of korsmayer papas were close to 1, Drug release from
formulation follows matrix diffusion kinetics. Hence, diffusion was the mechanism of the drug release from the medicated
chewing gums. Further, observed diffusion coefficient values are indicative of the fact that the drug release from the formulation
follows non-Fickian transport mechanism. Most Formulations released 50% of their contents within 25-30 minutes. Results
obtained from the accelerated stability studies are indicative of a slight reduction in flavonoids and phenolic contents with time
on long time storage. Initial on 0 days the concentration of flavonoid and phenolic contents was 72.98 mg/gm and 18.56 mg/gm
on 54th day it was observed 69.56 mg/gm and 16.50 mg/gm and on 90th day it was observed 67.78 mg/gm and 16.00 mg/gm
from the results it can be concluded that flavonoid and phenolic contents are reducing with time by the effect of the temperature
and moisture. When measured degradation under ambient conditions, degradation was significantly lower than in accelerated
stability study.
CONCLUSION
: The results of the study support the traditional application of the plants and suggest, plant extracts possess
compounds with antimicrobial properties that can be used as potential antimicrobial agents and gums can be a good carrier of
herbal extracts. Developed formulation will cure/protect from various periodontal diseases. Further development and evaluations
chewing gums including the isolated compounds on commercial scale and their clinical and toxicological studies are the future
challenges.
Biography
Dr. Reenu Yadav has completed her PhD at the age of 32 years fromNIMS University and postgraduate studies fromVNS Institute of Pharmacy, RGPV University. She is professor
in Bhabha Pharmacy Research Institute, Bhopal, a premier organization. He has authored 3 books, published more than 30 papers in reputed journals and has been serving as
an editorial board member of repute. She has lectured worldwide; she is member of many national and international bodies and awarded with many grants from government.
yadavreenu@gmail.comReenu Yadav et al., Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-002