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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
C
hewing gums are mobile novel drug delivery systems, with a potential for administering drugs either for local action or for
systemic absorption via buccal route. An antimicrobial chewing gum delivery system of the methanolic extracts of
Beatea
monosperma
(barks and twigs),
Cordia obliqua
(leaves and seeds) and
Cuminun cyminum
(seeds) against periodontal diseases
caused by some oral pathogens, was designed and characterized on various parameters.
INTRODUCTION:
Oral diseases are major health problems with dental caries and periodontal diseases among the most important
preventable global infectious diseases. The association between oral diseases and the oral micro biota is well established.
Several agents are commercially available these chemicals can alter oral micro biota and have undesirable side-effects such as
vomiting, diarrhea and tooth staining. Development of bacterial resistance to presently available antimicrobial agents and their
side effects has necessitated the search for new antimicrobial agent. Hence, the search for alternative products over synthetic
continues and natural, plant extracts and Phyto- chemicals isolated from plants used as traditional medicines are considered
as good alternatives. It was considered worldwide to explore Indian traditional medicinal plants for development of herbal anti
microbial chewing gum (as a novel drug delivery system) The aim of the present work was to develop a chewing gum with
antimicrobial activity which will cure/protect from various periodontal diseases such as periodontitis, gingivitis, and pyorrhea.
EXPERIMENTAL METHODS:
Plant materials procured from local suppliers, and authenticated by taxonomist Dr. Manjusa Saxena.
Extraction of plant materials was done bymethanol followed by preliminary investigations (Physical characteristics and qualitative
chemical tests) and standardization of extracts. Screening of antimicrobial activity was carried out with the help of disk diffusion
method against some gram positive (Streptococcus mutans, S.mitis and S.sanguis), gram negative (
A. actinomycetemcomitans,
P. gingivalis and B. forsythus)
and fungal strain (
Candida albicans
). Minimum inhibitory concentration assay was performed by
agar dilution method recommended by the National Committee for Clinical Laboratory Standards. Dried Extracts of
Beautea
monosperma, and Cordia obliqua,
sucrose, glycerol, dried extract of
Cuminum cyminum
as flavoring and coloring agent,
magnesium corbonate, and citric acid were added to melted wax and gum base at appropriate temperature. Antimicrobial chewing
gums were cut in to the pieces of suitable size and coated by acacia solution (2%w/w) sugar dusting followed by acacia-sugar-
calcium carbonate until a smooth surface was produced. Organoleptic characterization was performed at every stage of the
development of the formulation. Gum’s weight variation, thickness, hardness, friability, drug content uniformity were determined.
Standardization of the formulation was performed by taking nicco gum as standard marketed formulation. Release of drugs
was studied in pH 6.8 using a mastication device.Total phenolic and flavonoid contents were estimated by folin-Ciocalteu and
aluminium chloride method, and stability studies were performed (40oC and RH 75% ± 5% for 90 days) to assess the effect of
temperature and humidity on the concentration of phenolic and flavonoid contents. The results of accelerated stability conditions
were compared with that of samples kept at controlled conditions (RT). The control samples were kept at room temperature.
(25oC, 35% RH for 180 days.)
Formulation and Characterization of antimicrobial chewing
gum delivery of some herbal extracts for treatment of
periodontal disease
Reenu Yadav
1
, Yogesh Pounikar
1
, S.K. Yadav
2
1
IES College of P
1
Bhabha Pharmacy Research Institute , Bhopal, Madhya Pradesh, 462044, India
2
TIT College of Pharmacy, Bhopal, Madhya Pradesh, 462021, India;
yadavreenu@gmail.comReenu Yadav et al., Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-002