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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
In recent years, the whole field of ion-selective electrodes (ISEs) in
pharmaceutical sciences has expanded far beyond its original roots. The
diverse range of opportunities offered by ISEs was broadly used in a number of
pharmaceutical applications, with topics presented ranging from bioanalysis of
drugs and metabolites, to protein binding studies, green analytical chemistry,
impurity profiling, and drug dissolution in biorelevant media. Inspired from
these advances and with the aim of extending the functional capabilities of
ISEs, the primary focus of the present paper is the utilization of ISE as a tool
in personalized medicine. Given the opportunity to explore biological events in
real-time (such as drug metabolism) could be central to personalized medicine.
(ATR) is a chemo-degradable and bio-degradable pharmaceutically active drug.
Laudanosine (LDS) is the major degradation product and metabolite of ATR
and is potentially toxic and reported to possess epileptogenic activity which
increases the risk of convulsive effects. In this work, ATR have been subjected
to both chemical and biological hydrolysis, and the course of the reactions
is monitored by means of a ISE. In this study, we have designed an efficient
real-time tracking strategy which substantially resolve the challenges of the
ATR chemical and biological degradation kinetics. By utilizing a potentiometric
sensor, tracking of ATR chemical and biological degradation kinetics can be
performed in a very short time with excellent accuracy. The LOD was calculated
to be 0.23 molL−1, the potential drift was investigated over a period of 60 min
and the value was 0.25 mVh−1. Real serum samples for measuring the rate of in
vitro metabolism of ATR were performed. Furthermore, a full description of the
fabricated screen-printed sensor was presented.
Biography
Ahmed Ma'mun has his career in Pharmaceutical Industry for
almost 11 years in the field of analytical chemistry, methodology
and validation. Since 5 years, he is a Quality Control Supervisor
in Orchidia Pharmaceuticals for ophthalmic. He has been a
ResearcherinAnalyticalChemistryofFacultyofPharmacy,Cairo
University since 2012. His [Master’s Degree] is in hold for the
final discussion. His recent publication Real-time potentiometric
sensor; an innovative tool for monitoring hydrolysis of chemo/
bio-degradable drugs in pharmaceutical sciences" is published
in Journal of biomedical and pharmaceutical analysis. He is an
Editorial Board Member in Asian journal of Lifesciences. He is
an Invited Speaker and Plenary Speaker in many international
conferences worldwide.
Real-time potentiometric sensor; an innovative tool for
monitoring hydrolysis of chemo/bio-degradable drugs in
pharmaceutical sciences
Ahmed Ma'mun1, Mohamed K Abd El-Rahmana1 and Mohamed
Abd El-Kawy2
1Cairo University, Cairo, Egypt
2Future University, Cairo, Egypt
Ahmed Ma'mun et al., Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-002