20 / 20
Volume 4
Journal of Pediatric Care
ISSN: 2471-805X
Page 48
JOINT EVENT
Pediatric Critical Care 2018 &
World Pediatrics 2018
October 18- 20 , 2018
October 18- 20, 2018 Warsaw, Poland
&
6
th
International Conference on
25
th
World Pediatrics Conference
Pediatric Critical Care and Emergency Medicine
Juvenile onset Psoriatic arthritis (jPsA) share similar clinical characteristics with adult onset Psoriatic
Arthritis (PsA) but children report longer delay in diagnosis
Euthalia Roussou
and
Maria Di Cicco
King George Hospital, United Kingdom
T
o assess clinical and demographic characteristics retrospectively between those patients that had jPsA onset and those
that had Psoriatic Arthritis (PsA) disease onset as adults. A registry for Spondyloarhtropathies (SpAs) aiming to assess
patients’ disease progression over time (ethics approval REC: 07/H0701/74) was used as a source for the information required
for analysis. A questionnaire was given to be filed in by the patients when attending the clinic. The timing was as close to the
first attendance as possible (if it was not possible to be at the first attendance). The questionnaire had semi validated questions
and its validation has been published before. A total of 277 patients with established PsA were asked when did the disease start.
From the total of 277 there were responses enabling analysis from 220 patients (79.4%). From those 220 patients (mean age
51.14 sd 14.2 range 18-88) 13 patients (5.9%) reported age of onset below the age of 16 and classified as Juvenile onset group;
32 patients (14.5%) reported age of onset between 17 and 25 years and classified as adolescent group; 161 patients (73.1%)
reported age of disease onset between 26 and 64 and classified as adult onset, while 14 patients (6.3%) reported disease onset
above the age of 65. With the aim to further analyze the adult onset group we divided the group in 4 groups according to the
decade of their age of disease onset. These were; 26 to 35 years old, 36 to 45, 46 to 55 and 56 to 64 years old. Patients with
reported age of onset disease above the age of 65 were classified as geriatric group. From the PsA group data from the juvenile
onset PsA (jPsA) (n-13) were then compared with the adult group with the age of onset 56 to 65 years (n-22) as the numbers
of patients in the latter group and the gender distribution were similar to those of the jPsA group. In the total of 13 patients
identified with age of disease onset of below 16 years of age, data on arthritis, enthesitis, dactylitis, axial, peripheral disease
or both, HLAB27 status, disease duration, delay in diagnosis and the indices BASDAI BASFI , sleep disturbance, wellbeing
over past week and treatment effect were collected . Same data collected from the adult group and comparison took place
between the 2 groups. Statistical analysis was performed using the SPSS statistical program and the differences between groups
were calculated using chi square t tests. The male to female distribution according to the age of onset showed that there are
slightly more boys in the juvenile group (M:F = 7:6) and equal gender distribution in the 56 to 64 age group (M:F 11:11).
When we looked and compared the juvenile onset PsA group with the middle age 56 to 65 adult onset group similar disease
characteristics were found as per table. The treatment that the patients were in was different in that more juvenile onset patients
were on biologics, and immunotherapy medication while more adults were on NSAIDs (12 patients in the adult onset group
(representing 54.5%) vs 3 patients in the jPsA onset (23%) and had surgery at the time of the assessment (5 adults (22.7%) vs 1
in jPsA (7.6%) (p=0.06). However the effect of treatment was similar.
thaliaroussou@hotmail.comJ Pediatr Care 2018, Volume 4
DOI: 10.21767/2471-805X-C4-015