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Notes:
Volume 4
Journal of Pediatric Care
ISSN: 2471-805X
Page 41
JOINT EVENT
Pediatric Critical Care 2018 &
World Pediatrics 2018
October 18- 20 , 2018
October 18- 20, 2018 Warsaw, Poland
&
6
th
International Conference on
25
th
World Pediatrics Conference
Pediatric Critical Care and Emergency Medicine
J Pediatr Care 2018, Volume 4
DOI: 10.21767/2471-805X-C4-015
Analysis of susceptibility genes of children with severe cutaneous adverse drug reactions
Yuan Liang
Capital Medical University, China
S
evere drug eruption (severe cutaneous adverse reactions, SCAR) refers to a group of life-threatening severe cutaneous
adverse reactions of drugs characterized by the skin and mucous membrane involvement which includes Steven-Johnson
syndrome (SJS) and toxic epidermal necrosis necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS)
and acute generalized exanthematous pustulosis (AGEP). Severe drug eruption in children is a kind of severe drug eruption
occurring within the age group of 14 years old. Because of the particularity of children, they are different from adults. The
pathogenesis of severe drug eruption has not been fully elucidated, but pharmacogenetics studies have confirmed that some
SCARs caused by specific drugs are associated with individual human leukocyte antigen (human leukocyte antigen, HLA)
allele types. Associations of abacavir and HLA-B*57:01, carbamazepine and HLA-B*15:02, allopurinol and HLA-B*58:01,
dapsone and HLA-B*13:01 were widely reported and the effectiveness have been confirmed. It is possible to detect the specific
risk loci to prevent the occurrence of severe drug eruptions. However, the HLA allele has its own characteristics such as
population heterogeneity (i.e.,the same SCARs is different in different ethnic groups related to the HLA allele), non-uniqueness
(i.e., the same HLA allele may be associated with different drug reactions, and different types of drugs reactions induced by the
same drug may be associated with different HLA alleles). we need to find more relevant HLA risk loci that can trigger drugs-
related SCARs and look for other susceptibility genes.
hxfaily@aliyun.com