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PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 25
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
Background: Polycystic ovary syndrome (PCOS) is a
heterogeneous disorder encompassing hyperandrogenism and
metabolic disturbances. Androgen excess may correlate with
metabolic risk; a lack of clarity persists regarding the specific
androgen to be measured.
Aims & Objectives: To determine the association of total
testosterone (TT) to dihydrotestosterone (DHT) ratio in
assessing the adverse metabolic parameters in PCOS.
Material and method: This study included 44 PCOS women
(age, mean±SD: 23.1±4.86 years; body mass index, BMI:
25.78±4.38 kg/m2), recruited on basis of Rotterdam criteria
and 44 healthy age matched controls (age, mean±SD:
23.02±4.28 years; BMI: 20.80±3.33 kg/m2). After taking the
history, physical examination and anthropometric data in all
participants, TT, sex hormone binding globulin (SHBG) and
insulin were measured by chemiluminescent immunoassay
while DHT by ELISA. TT/DHT ratio, free androgen index (FAI)
(TT/SHBG*100) and insulin resistance (homeostatic model
assessment (HOMA-IR)) were calculated.
Results: PCOS patients showed significantly higher levels
of TT (70.46±27.54 vs. 31.31±13.84 ng/dl; p<0.001), and
FAI (11.24±9.00 vs. 3.03±2.30; p<0.001), and a low SHBG
(35.00±31.99 vs. 47.07±23.86 nmol/l; p=0.048) compared to
healthy controls. The TT/DHT ratio was significantly higher
in PCOS patients (3.62±2.53 vs. 2.06±1.19; p<0.001), no
significant difference were found for DHT (p=0.282). In PCOS
patients, TT/DHT ratio was significant for impaired glucose
tolerance (IGT) (P=0.038) but not for metabolic syndrome
(p=0.931), obesity (p=0.094) and insulin resistance (p=0.886).
Furthermore, the TT/DHT ratio was found to be high for
obese (p=0.004), insulin resistant (p=0.026) and high waist
circumference (WC, p=0.002) subjects, irrespective of any
group.
Conclusion: TT/DHT ratio may be a useful surrogate marker for
adverse metabolic parameters in PCOS..
Biography
Sukanti Shah is a Resident Doctor studying MD in the Department of Endo-
crinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka,
Bangladesh. She has attended and presented posters in reputed national
and international conferences. She is also working as a member in PCOS
Study Group. Her research interests are in PCOS, Infertility and Obesity.
Ratio of total testosterone to dihydrotestosterone as a
marker of adverse metabolic parameters in polycystic ovary
syndrome
Sukanti Shah, Hurjahan Banu, Sharmin Jahan and M A Hasanat
Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh
Sukanti Shah et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-002