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PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 23
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
Background: Polycystic ovary syndrome (PCOS) is a
heterogeneous disorder of uncertain etiology.
Objectives: To see the phenotypes and frequencies of insulin
resistance and metabolic syndrome in PCOS.
Materials & Methods: This study included 100 PCOS women
(age, mean±SD: 23±5 years; body mass index, BMI: 27.6±4.6
kg/m2), recruited on the basis of Rotterdam criteria and 25
healthy controls (age, mean±SD: 24±5 years; BMI: 24.2±4.9
kg/m2). Hormonal analysis was done using chemiluminescent
immunoassay. PCOS phenotypes were defined as: A (oligo-
anovulation + hyperandrogenism + PCO), B (oligo-anovulation
+ hyperandrogenism), C (hyperandrogenism + PCO) and D
(oligo-anovulation + PCO).
Results: Frequency of PCOS phenotypes were highest for A
(57%), followed by D (16%), B (14%) and C (13%). BMI, waist
circumference (WC), waist/hip ratio and Ferriman-Gallwey (FG)
score showed statistically significant difference when control
group was included, but not among the PCOS phenotypes.
Highest value of fasting insulin was observed in A followed by
D, B and C, and all were higher than control. Frequencies for
pre-diabetes, insulin resistance and metabolic syndrome were
significantly higher in PCOS. Phenotypes (A vs. B vs. C vs. D)
also showed difference for total testosterone (85.82±28.44
vs. 82.84±22.7 vs. 76.09±27.5 vs. 34.35±5.17 ng/dl; p<0.001);
testosterone was higher in A, B, C but all had significantly higher
level than D (p<0.001 for all). Homeostatic model assessment
(HOMA-IR) significantly correlated with BMI, fasting blood
glucose, 2-h glucose, total cholesterol and triglyceride in
PCOS. Logistic regression showed that age > 25 years, WC
> 80 cm, BMI > 25 kg/m2, and FG score were risk factors for
metabolic syndrome. Using IR as a dependent variable, A and C
was associated with 17-fold, 13-fold and 11-fold increased risk
of developing insulin resistance, while phenotype D with 9-fold
compared to control.
Conclusions: Phenotype A is the most common, followed by
others, while A and B have adverse metabolic outcome.
Biography
Hurjahan Banu is presently working in the PCOS Study Group and holds an
FCPS Degree in Endocrinology. She is currently a Post-graduate Fellow and
a permanent Staff Researcher in the Department of Endocrinology, Bangab-
andhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Her
research interests are in PCOS, Infertility, Obesity, Diabetes and Thyroid Dis-
orders. She has already published few articles in national and international
journals.
Insulin resistance and metabolic syndrome among different
phenotypes of women with polycystic ovary syndrome
Hurjahan Banu and M A Hasanat
Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh
Hurjahan Banu et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-002