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Pain Management 2019 & Internal Medicine 2019
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 44
JOINT EVENT
7
th
Edition of International Conference on
Pain Management
8
th
Edition of International Conference on
Internal Medicine &
Patient Care
&
March 25-26, 2019
Rome, Italy
Ivan R Jeremic et al., Int J Anesth Pain Med 2019, Volume 5
DOI: 10.21767/2471-982X-C1-006
Possible DRESS syndrome in a patient with systemic
sclerosis and rheumatoid arthritis during treatment with
lamotrigine
Ivan R Jeremic
1
and
Predrag Ostojic
1, 2
1
Institute of Rheumatology, Serbia
2
University of Belgrade, Serbia
D
rug Reaction with Eosinophilia and Systemic
Symptoms (DRESS) syndrome is a severe, potentially
life-threatening idiosyncratic drug reaction, usually
caused by anti-epileptics, antibiotics or non-steroidal
anti-inflammatory drugs, after a latency period of
three weeks to three months. Typical clinical features
include mucocutaneous rash, fever, lymphadenopathy
and internal organ involvement. We report a patient
with systemic sclerosis, rheumatoid arthritis and
osteoporosis, who developed possible DRESS syndrome
to lamotrigine, used to treat epilepsy. Clinical features
suggesting DRESS syndrome includes severe rash,
fever, lymphocytopenia and thrombocytopenia. The
condition was initially unsuccessfully treated as an
acute allergic reaction to ibandronate with parenteral
glucocorticosteroid and antihistamine. This report
aims to increase the awareness of this rare entity in the
rheumatology community.
Biography
Ivan Jeremic has completed his Research Master’s Degree in
Rheumatology from Belgrade School of Medicine and Clinical
medicine PhD candidate at Novi Sad University.
ivanjeremic@rocketmail.com