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Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
August 16-17, 2018
Dublin, Ireland
Organic Chemistry 2018
Page 29
6th Edition of International
Conference and Exhibition on
Organic Chemistry
Novel enantioselective organocatalytic transformations
involving Rauhut Currier (RC) reaction will be presented.
The reaction started from symmetrical cyclohexadienones and
allenoates to give tetrahydrobenzofuranones bearing a chiral
tetrasubstituted stereogenic center in up to 96% ee with high
diastereo-, regio-, and chemo-selectivity. In addition, a facile
method for the construction ofmethylidenelactams will also
be introduced. The reaction proceeds via an amidation/RC
reaction sequence starting from symmetrical cyclohexadienone
derivatives and acryloyl chloride promoted by a newly developed
chiral acid-base type organocatalyst.
Biography
Hiroaki Sasai pursued PhD in 1985 from Keio University, Tokyo, Japan. Af-
ter working as an Assistant Professor at Hokkaido University, he moved to
the University of Tokyo (Lecturer and then Associate Professor) in 1992
and then moved to the current position in 1997. He is a recipient of 1995
PSJ Award for young scientists and the Fluka Prize "Reagent of the Year
1996". He also received CSJ Award for Creative Work in 2006, the Molecu-
lar Chirality Award in 2011, Synthetic Organic Chemistry Award in 2016 and
Commendation for Science and Technology by the Minister of Education,
Culture, Sports, Science and Technology, Japan in 2018. His research in-
terests lies in enantioselective catalysis and conceptually new functional
materials.
Hiroaki Sasai
The Institute of Scientific and Industrial Research, Osaka University, Japan
Hiroaki Sasai, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-010
Novel enantioselective organocatalytic
transformations involving Rauhut Currier
reaction