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Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
August 16-17, 2018
Dublin, Ireland
Organic Chemistry 2018
Page 28
6
th
Edition of International
Conference and Exhibition on
Organic Chemistry
U
sing two different highly non-equilibrium synthetic
approaches, we have created new kinds of stable oil-in-water
nanoemulsions composed of complex multi-compartment
nanoscale droplets. Each nanodroplet contains three
different types of mutually immisible oils in separate internal
compartments. Consequently, each internal compartment can
hold a different class of oil-soluble drug molecules. By analogy
to Janus droplets, which contain two different immiscible oil
types and are named after the mythological two-faced deity of
doorways, we call these compartmentalized triple-oil droplets
“Cerberus” droplets, after three-headed watch-dog in the same
mythology. Inafirst synthetic approach, we combine three simple
microscale oil-in-water emulsions, each made using a different
oil type (aliphatic, aromatic, or fluoro siloxanes), and subject
this mixed microscale emulsion to extreme flow conditions
using a high-pressure microfluidic homogenizer. In addition to
causing droplet rupturing towards the nanoscale, the extreme
flow also overcomes the stabilizing interfacial repulsion of the
water-soluble ionic surfactant, leading to flow-induced droplet
fusion. The multi-compartment nanodroplets in these complex
oil-in-water nanoemulsions are so small that optical microscopy
methods cannot resolve the internal interfaces that separate
the internal compartments. So, instead, we have developed the
use of cryogenic transmission electron microscopy (C-TEM)
to reveal the compartmentalization of these three oils inside
the resulting Cerberus nanodroplets. In a second approach,
we create Cerberus droplets using self-limiting droplet fusion
reactions obtained by transiently destabilizing a mixed emulsion
containing droplets of the three different oil types using an ionic
amphiphile having the opposite charge. Based on these results,
we create a classification scheme for different kinds of Cerberus
droplet morphologies. In pharmaceutical applications, Cerberus
nanoemulsions can be tailored to provide local co-delivery of a
wide range of non-aqueous drug molecules, thereby overcoming
limitations related to poormolecular solubility in certain oil types.
Biography
Thomas G Mason received his PhD from Princeton University (USA) in
1995. He completed a first Postdoc at the CNRS Paul Pascal Research In-
stitute in Bordeaux in physical chemistry and a second Postdoc at Johns
Hopkins University in chemical and biomolecular engineering. Following
6 years as a principal investigator research scientist in industry, in 2003,
he joined University of California Los Angeles as an Assistant Professor
of physical chemistry and physics. He was promoted to Full Professor in
2009. He has published more than 120 papers in peer-reviewed journals
and is an Inventor on 15 issued patents. He has received Princeton’s Jo-
seph Henry Prize, Intel’s New Faculty Award, and NSF’s CAREER Award,
and is a Fellow of the Americal Physical Society.
.
mason@chem.ucla.eduThomas G Mason
University of California Los Angeles, USA
Thomas G Mason, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-010
Synthesis of multi-compartment
nanoemulsions for localized co-delivery
of different classes of oil-soluble drug
molecules