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J Obes Eat Disord, 2017
ISSN: 2471-8203
August 23-24, 2017 | Toronto, Canada
allied
academies
INTERNATIONAL OBESITY, BARIATRIC AND
METABOLIC SURGERY SUMMIT AND EXPO
O
besity has become an increasing problem over recent
years. Nano lipo-vesicles hydrogels of soy saponin were
formulated and evaluated in an attempt to reduce the size
of adipose tissue cells through percutaneous absorption.
Phytosome formulations were prepared with four different
techniques namely: Solvent evaporation, anti-solvent
precipitation, co-solvency and mechanical dispersion.
Best formulae was selected by the means of the highest
entrapment efficiency, minimum particle size and maximum
drug release and then evaluated for successful complex
formation by means of FTIR. Particles zeta potential was
detected and particles shape was evaluated using TEM
to insure particles spherical shape. Selected phytosome
formulae were involved into selected hydrogel formulae
after evaluation of different plain hydrogel formulations for
its clarity. Homogenity, pH, gel transforming temperature
and viscosity study obtained phytosomal hydrogel formulae
was then re-evaluated for its clarity, homogeneity, pH and
gel transforming temperature and for its rheology behavior
and permeation study.
In vivo
study was done to ensure anti
-obesity effect of soy phytosomal hydrogel. Concisely, soy
phytosomal hydrogel was found to have the ability to reduce
the size of adipose tissue cells in male albino rats.
e:
nermeen.magdy@nub.edu.egNano sized soy phytosome-based thermogel formulation for treatment of obesity, characterization
and
In vivo
evaluation
Nermeen M Abd El-Sater
1
, Shahira F El-Menshawe
2
, Adel A Ali
2
and
Mohamed A Rabeh
3
1
Nahda University, Egypt
2
Beni-Suef University, Egypt
3
Cairo University, Egypt
J Obes Eat Disord, 3:2
DOI: 10.21767/2471-8203-C1-003