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Volume 4, Issue 2 American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3rd World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
STVNa, a promising medicine for cardiac protection
Wen Tan
Guangdong University of Technology, China
C ardiac ischemia or hypertrophy involves multiple mechanisms and may lead to heart failure. Few medicines are now available for
effective treatment. STVNa, derived from Stevia, has been shown beneficial effects in protection of acute cardiac ischemia. Our
recent studies demonstrated that in animals with chronically coronary occlusion, consecutive oral treatment of STVNa significantly
ameliorated the deterioration of cardiac function with reduced area of infarction and apoptosis. Long-term treatment of STVNa in
Transverse Aortic Constriction (TAC) rats also protected the heart from fibrosis and hypertrophy remodeling and improved both
cardiac systolic and diastolic function. In isoproterenol treated ventricular myocytes, STVNa reduced hypertrophy, inhibited the
increases in cytosol calcium or ROS, and preserved contractility and mitochondrial membrane potential. Proteomic analysis, cell
biochemistry and electrophysiological studies indicated that STVNa protected the heart against fibrosis and remodeling of metabolite
and electrophysiology during ischemia and/or reperfusion injury or hypertrophy.
Biography
Wen Tan is a Professor and Dean at Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China. He has his
expertise in “Thousand Talents” plan in China (2012). Professor Tan earned his medical degree at HB Medical School in China and earned his PhD. from University
of Nebraska Medical Center in USA. After post-doc trainings at Harvard Medical School, he joined Howard Hughes Institute& Columbia University in USA as an
associate research scientist and research assistant professor. In late of the nineties, he returned to China as a founder of a pharmaceutical research company
which has successfully registered more than ten generic & innovative drugs for China market since.
Wen Tan, American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-002