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Nano Research & Applications
ISSN 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotechnology &
Smart Materials
O c t o b e r 0 4 - 0 6 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Nanotechnology & Smart Materials 2018
Delivery of docetaxel to breast cancer cells employing water
soluble carbon nanotubols: enhanced anti-neoplastic activity and
improved pharmacokinetic profile
Nagarani Thotakura, Kaisar Raza and Vipin Kumar
Central University of Rajasthan, India
I
n the present research, the aimwas to synthesize aspartic acid tagged water soluble hydroxylated CNTs (CNTnols) and to deliver
docetaxel to cancer cells with enhanced safety and efficacy. Various characterization studies like FT-IR and NMR spectroscopy
were performed after synthesizing docetaxel conjugated aspartic acid derivatized CNTnols. Particle size analysis, zeta potential,
PDI and FE-SEM were also used for characterization of the nanoconjugate. Release kinetics, cytotoxicity assay, cellular uptake
studies and pharmacokinetics and other methods were used for evaluation of conjugate. From cell viability studies, it was found
that there was 4.05 times decrease in IC50 values after conjugation showing the targeted action. Cellular uptake studies are in
support with cytotoxic studies proving the enhancement in cellular uptake of docetaxel. Through pharmacokinetic studies it was
observed that the half-life and bioavailability was increased by 6 and 4.3 times when compared to pure drug. It was found that the
synthesised nanoconjugate was hemocompatible and offered low protein binding. All the findings are promising in nature and
the nanoconjugate was considered as a novel carrier for delivery of anti-cancer drugs, especially belonging to bio pharmaceutics
classification system (BCS) class IV.
nagaranithotakura2@gmail.com 2015phdpharm04@curaj.ac.inlNano Res Appl Volume:4
DOI: 10.21767/2471-9838-C6-025