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Nano Research & Applications
ISSN 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotechnology &
Smart Materials
O c t o b e r 0 4 - 0 6 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Nanotechnology & Smart Materials 2018
New potentiometric sensor based on molecularly imprinted
nanoparticles for cocaine detection
O Sheej Ahmad, K Smolinska Kempisty, A Guerreiro, K Karim, E
Piletska and S Piletsky
University of Leicester, UK
H
ere, we present a potentiometric sensor for cocaine detection based on molecularly imprinted polymer nanoparticles
(nanoMIPs) produced by the solid-phase imprinting method. The composition of polymers with high affinity for cocaine
was optimized using molecular modelling. Four compositions were selected and polymers prepared using two protocols:
chemical polymerisation in water and UV-initiated polymerisation in organic solvent. All synthesised nanoparticles had very good
affinity to cocaine with dissociation constants between 0.6 nM and 5.3 nM. However, imprinted polymers produced in organic
solvent using acrylamide as a functional monomer demonstrated the highest yield and affinity. For further sensor development,
nanoparticles were incorporated within a PVC matrix which was then used to prepare an ion-selective membrane integrated with
a potentiometric transducer. It was demonstrated that the sensor was able to quantify cocaine in blood serum samples in the
range of concentrations between 1 nM and 1mM
.
osa14@le.ac.ukNano Res Appl Volume:4
DOI: 10.21767/2471-9838-C6-025