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NanoMat 2018
Nano Research & Applications
ISSN: 2471-9838
Page 47
April 26-27, 2018
Rome, Italy
17
th
Edition of International Conference on
Emerging Trends in
Materials Science and
Nanotechnology
I
n recent years, among the broad research field in materials
science, microgel particles have received considerable
attention as controlled delivery systems. Microgel particles are
environmentally responsive particles with incomparable chemical
and physical versatility. These stem from the unique combination
of their simple synthesis, large surface area, variation of their
volume in response to different stimuli, and their ability to contain
different types of small molecules and even macromolecules
due to their porous structure. These properties make them an
outstandingpotential choice tobe usedas effective smart delivery
systems. Although the design of microgels will be dependent on
the requirements established by the specificity of the application,
current developments tend to prepare multi-responsive microgels
that respond simultaneously to a combination of several stimuli
in order to obtain more effective delivery systems. In this sense,
thermo- and pH-sensitive microgels have received significant
attention as smart delivery systems. Concerning delivery
applications, the design of innovative delivery systems is resulting
in the new product development in cosmetic. The key parameter
for achieving the most effective cosmetic and personal care
products is the controlled release of active cosmetic molecules
to the target site of action on/in the skin. Therefore, the design
of the sophisticated and effective targeted delivery systems is
considered to be the panacea of modern cosmetic. Herein, the
potential application of different multi-responsive oligo (ethylene
glycol)-based microgels as smart delivery systems of different
cosmetic active molecules (hydrophobic, hydrophilic and
macromolecules) has been studied. In addition, those microgels
have been taken to the next level producing multi-responsive self-
assembled microgel films from a fast bottom-up approach. The
results obtained indicate that multi-responsive oligo (ethylene
glycol)-based microgels and films are new potential vehicles to
design sophisticated and controllable cosmetic active delivery
systems.
Recent Publications
1. Aguirre G, Ramos J and Forcada J (2016) Advanced
design of T and pH dual-responsive PDEAEMA-PVCL
core-shell nanogels for siRNA delivery. Journal of
Polymer Science Part A: Polymer Chemistry 54:3203-
3217.
2. Aguirre G, Villar-Alvarez E, Gonzalez A, Ramos J,
Taboada P and Forcada J (2016) Biocompatible
stimuli-responsive nanogels for controlled antitumor
drug delivery. Journal of Polymer Science Part A:
Polymer Chemistry 54:1694-1705.
3. Pikabea A, Aguirre G, Miranda J I, Ramos J and
Forcada J (2015) Understanding on nanogels swelling
behavior through a deep insight into their morphology.
Journal of Polymer Science Part A: Polymer Chemistry
53:2017-2025.
4. Aguirre G, Ramos J, Heuts J P A and Forcada J (2014)
Design and potential cosmetic applications of multi-
responsive microgels and self-assembled microgel films
Garbine Aguirre
1,2
, Abdelouahed Khoukh
1
, Kamel Chougrani
2
, Valérie Alard
2
and
Laurent Billon
1
1
University of Pau and Pays de l’Adour, France
2
LVMH Recherche, France
Garbine Aguirre et al., Nano Res Appl, Volume:4
DOI: 10.21767/2471-9838-C1-008
Figure 1:
Scheme of cosmetic active molecules encapsula-
tion process into multi-responsive microgel and films.