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Medchem & Toxicology 2018
Page 30
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
B
eta-cyclodextrins are widely used excipients in pharmaceuticals and
foods. Nowadays extensive research is focused on the cyclodextrin-
based therapy of cholesterol-releated disorders such as neurodegenerative
and cardiovascular diseases. The conventional application of cyclodextrins
is the solubility and absorption enhancement of poorly soluble drugs by the
formation of host-gust complexes. On the other hand cyclodextrins can interact
with natural cell membrane components like cholesterol or phospholipids.
At high concentration it causes membrane damage and cell death, which is
responsible for their cytotoxicity. A new renaissance started in the research
and application of cyclodextrins a few years ago. The number of novel
derivatives are increasing and new applications has been appeared especially
in the field of cell biology and drug delivery. Recently it was discovered, that
cyclodextrins are internalized into different cell types by endocytosis at
non-toxic concentrations and this phenomenon opens new perspectives in
the application of cyclodextrins. Hydroxypropyl beta cyclodextrin (HPBCD)
and sulfobutyl ether sodium formulation excpient (SBEBCD) derivatives are
safe and considered to be non-toxic. Therefore, they appeared in parenteral
applications and recently HPBCD was approved as an orphan drug in the
treatment of a cholesterol storage disorder, Niemann-Pick Disease Type C.
Biography
Miklos Vecsernyes has completed his degree of Pharmacy in
1982 and his PhD at 1997 from Albert Szent-Gyorgyi Medical
School, Szeged, Hungary. He is the Director of Department
of Pharmaceutical Technology, and the Dean of Faculty of
Pharmacy, University of Debrecen. He has published more
than 100 papers in reputed journals and has been serving
as Rreviewer of several journals. His scientific interest is
focused on Biopharmacy, Neuroendocrinology, Absorption
and Bioavailability of Drugs and Pharmaceutical Excipients,
especially Cyclodextrins.
vecsernyes.miklos@pharm.unideb.huApplication of beta-cyclodextrins: from formulation to orphan drug
Miklos Vecsernyes
1
, Ferenc Fenyvesi
1
, Judit Varadi
1
and Ildiko
Bacskay
1
University of Debrecen, Hungary
Miklos Vecsernyes et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-008