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Medchem & Toxicology 2018
Page 42
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
T
he metastatic disease significantly decreases the survival rate of patients
with head and neck squamous cell carcinoma (HNSCC). Src, a non-receptor
tyrosine kinase, plays critical roles in tumor progression and metastasis.
However, whether to effectively inhibit the function of Src in HNSCC remain
elusive.Wereport, for thefirst time, blockadeof Srckinaseactivityby saracatinib
which effectively suppressed invasion and metastasis of HNSCC in preclinical
animal models. Mechanistic assessment of the drug effects in HNSCC cells
showed that saracatinib induced suppression of invasion/metastasis through
downregulating the expression levels of Vimentin and Snail proteins and
reversing Src-dependent epithelial-mesenchymal transition. In tests in mice,
saracatinib was loaded into the novel multifunctional nanoparticles exhibited
superior effects on suppression of HNSCC metastasis compared with free
drug, which is mainly attributed to highly specific and efficient tumor-targeted
drug delivery system. These findings and advances are of great importance to
the development of Src-targeted nanomedicine as a novel treatment modality
against HNSCC, especially for more extensive tumors.
Biography
Dr. Teng earned his Ph.D. from Sun Yat-sen University in
2007. He is an Assistant Professor in the Dept. of Oral Bio at
AU. He has authored more than 70 articles and chapters in
reputed journals and books and serves on the grant review
panels of CDMRP-PCRP-Ad-CET, NYUAD, and NFSC. He has
demonstrated an excellent commitment to serve the scientific
community through numerous editorial and reviewing activities.
yteng@augusta.eduBlocking metastatic properties of head and neck cancer by
multifunctional nanoparticle-based saracatinib
Yong Teng
1,4,5
, Liwei Lang
1
, Chloe Shay
2
and Xuli Wang
3
1
Dental College of Georgia, Augusta University, Augusta, GA, USA
2
Emory Children’s Center, Emory University, Atlanta, GA, USA
3
University of Utah, Salt Lake City, UT, USA
4
Medical College of Georgia, Augusta University, Augusta, GA, USA
5
College of Allied Health, Augusta University, Augusta, GA, USA
Yong Teng et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-008