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Medchem & Toxicology 2018
Page 27
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Endophytic bacteria are the bacteria which reside in symbiotic association
inside the cell. They have been shown to produce the same metabolites as
that of seaweeds from which they are isolated. They also show many unusual
but useful characteristics like production of vitamins, growth hormones for
seaweeds, some host defence chemicals and metabolites. These endophytes
can be isolated from the seaweeds and can be analyzed for their different
activities in-vitro using different methods. Marine macroalgae are known
to carry diverse bacterial communities which interact with their hosts in
both harmful and beneficial ways. Algae hosts provide the bacteria with a
rich source of carbon in the form of carbohydrate polysaccharides such
as fucoidan, agar and alginate, which the bacteria enzymatically degrade.
Thus, the major objective of the present study was to isolate, identify and
characterize endophyte bacterial communities of different seaweed species
Antibiotic peptides are one of the most important secondary metabolites
produced by bacteria. These peptides are potent, broad spectrum antibiotics
which demonstrate potential as novel thearapeutic agents. Due to vast array
of resistivity against antibiotics shown by microorganisms; thus need of
antimicrobial agent has come on the market last 30 years. The solution to this
problem is peptide antibiotics. Peptide antibiotics have direct activity on the
cell-wall of microorganisms causing disruption of cell membrane. Endophytic
bacterial isolates were identified to species level by 16S rRNA gene sequence
homology analysis and encompassed Gram-negative and Gram positive
bacterial taxa. All bacterial isolates were screened for antimicrobial activity
against the pathogenic test strains. This study provides the first account of
the diversity and composition of bacterial populations of endophytes and
demonstrates the ability of these bacteria to produce antimicrobial compounds.
Despite recent advances in metagenomics, this study highlights the fact that
traditional culturing technologies remain available tool for the discovery of
novel bioactive compounds of bacterial origin.
Keywords— Sea-weeds, endophytic bacteria, antibiotic peptides, antimicrobial
activity, protein purification, 16S rRNA sequence homology.
Biography
Dr. Chanda V. Berde Parulekar has completed her PhD at the age
of 28 years from Microbiology Department of Goa University,
Goa, India following 2 years of postdoctoral studies from the
same department. She is involved in teaching and research in
the field of Biotechnology for the past 12 years. She has 30
research publications in reputed journals, 2 book publications,
2 chapters in books in the pipeline and is an Editorial board
member of JPABS. She has guided 62 research projects
in Biotechnology andMicrobiology. She has also attendedmore
than 15 conferences, national and international. She is on the
Board of Directors of Society for Environment, Biodiversity and
Conservation, India.
Antibiotic peptides and antimicrobial secondary metabolites
from endophytes of seaweeds
Chanda V. Berde-Parulekar1 and Upendra Lele 2
1Assistant Professor,Gogate Jogalekar College, Ratnagiri, Maharashtra. India.
Microbiology student, Gogate Jogalekar College, Ratnagiri, Maharashtra, India.
Chanda V. Berde-Parulekar et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-008