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Medchem & Toxicology 2018
Page 47
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Male reproductive function integrates delicate biological systems (tissues
and gametes) strongly susceptible to a myriad of factors including
man made engineered nanomaterials, heavy metals and metalloids. Metal-
based nanoparticles (NPs) are broadly used in biomedical field especially
as drug delivery systems, therapy in some pathologies namely cancer, and
imaging. Furthermore, its application on assisted reproductive technologies
is also emphasized. It is also worth noting for example, the benefits of
nanoselenium in sperm motility in experimental models. However, strong
evidences demonstrate the adverse impact of these nanosystems, and some
metal compounds on reproductive hormonal axis, and spermatogenesis
in animal models and man. Semen quality decay is largely referred at both
occupational and environmental settings. This work critically analyses the
up-to-date information of the influence of some metal-based nanoparticles
(eg. Au-NPs, ZnO-NPs), metals (eg. lead, cadmium, and chromium) on male
reproductive health. In addition, data from our preclinical studies will be
focussed on genotoxicity trials, antioxidant biomarkers, histopathological,
and ultrastructural tools. In addition semen analysis will be highlighted. Some
discrepancies in the literature were reported among experimental studies
due to different procedures in experimental design (dose, route of exposure,
and duration). However, in general, the factors mentioned above affect male
reproductive health, through oxidative stress which results in reversible and/
or irreversible changes in testosterone-producing cells, spermatogenesis,
and sperm quality parameters. Heavy metals such as cadmium induce severe
damage into the blood-testicular barrier, thus compromising fertility.
Biography
M L Pereira is an Associate Professor with Habilitation at
Department of Medical Sciences, University of Aveiro, and
Member of the Associate Laboratory CICECO-Aveiro Institute of
Materials. She got her PhD in Biology (Animal Cytology) at the
University of Aveiro. Her teaching activities include essentially
Cytology andHistology, and Cell Biology. Shewas Director of the
Master on Molecular and Cell Biology (2008-2018) at University
of Aveiro. Her research has been focused on the adverse effects
of heavy metals, nanoparticles, and pesticides on animal
models, especially male reproductive function, combining
histological, cell biology and ultrastructural approaches. She
co-authored more than several papers in international journals,
and has been serving as an Editorial Board Member of some
journals, acting also as referee.
Metal-based nanoparticles and heavy metals on spermatogenesis:
preclinical studies
Maria de Lourdes Pereira
CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal
Maria de Lourdes Pereira, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-008