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A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Medchem & Toxicology 2018
Page 37
B
aicalein (5, 6, 7-trihydroxyflavone) is a flavone, originally isolated from the
roots of
Scutellaria baicalensis
and
Scutellaria lateriflora
. It is also reported in
Oroxylum indicum
or Indian trumpet flower. It is the aglycone of baicalin. The roots
of
Scutellaria baicalensis
have been used to treat pulmonary infection traditionally
in Asia. The water extract of Scutellaria radix is known to have anti-inflammatory
effects. However, the effect of baicalein on virus-induced macrophages has
not been fully elucidated. In the present study, the anti-inflammatory effects
of baicalein on double-stranded RNA (dsRNA)-induced macrophages were
examined. Polyinosinic-polycytidylic acid (poly I: C), a synthetic analog of dsRNA,
was used to induce RAW 264.7 cells in this study. Baicalein significantly inhibited
the production of interleukin (IL)-1α, IL-6, IL-10, interferon gamma-induced
protein 10, granulocyte macrophage-colony stimulating factor, leukemia inhibitory
factor (IL-6 class cytokine), lipopolysaccharide-induced CXC chemokine (LIX),
monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and
vascular endothelial growth factor as well as calcium release and the mRNA
expression of signal transducer and activator of transcription 1 (STAT1), STAT3,
CHOP (GADD153), and FAS (CD95) in poly I:C-induced RAW 264.7 cells (P<0.05).
Thus, the present results suggest that baicalein has anti-inflammatory properties,
associated with its inhibition of cytokines, chemokines and growth factors in poly
I: C-induced macrophages via the calcium-CHOP/STAT pathway.
Biography
Wansu Park has completed his PhD from Kyung Hee University
and Postdoctoral studies from Kyung Hee University College
of Korean Medicine. He is the Chief Professor of Pathology
in College Of Korean Medicine, Gachon University. He has
published more than 25 papers in reputed journals. He has
served as the Chief Vice President of 「The Association of
Korean Medicine」 in Republic of Korea from 2013 to 2017.
pws98@gachon.ac.krAnti-inflammatory effects of baicalein
on RAW 264.7 mouse macrophages induced
with polyinosinic-polycytidylic acid
Young-Jin Kim, Hyun-Ju Kim, Ji Young Lee,
Do-Hoon Kim and Mi Suk Kang
College of Korean Medicine, Gachon University, Republic of Korea
Young-Jin Kim et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-007
Structural formula of flavonoid baicalein