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A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Medchem & Toxicology 2018
Page 38
A
review of the design process used to incorporate a patented spinning tube
in a tube (STT®) reactor into a continuous pharmaceutical process for the
manufacture of multi-component, single-pass, 2-aminothiophene derivatives
is presented. Also the role and utilization of ChemCad® process simulation
software and its integration with Comsol® computational fluid dynamics (CFD)
modelling will be discussed. These results will demonstrate the advantages of
using the STT® reactor in a continuous flow application in pharma applications.
In addition to the benefits gained in discovering new approaches to chemical
reaction synthesis, this continuous flow reactor can accelerate reaction rates by
up to 5,000 times in some cases and can handle slurries, gas-liquid reactions,
and liquid-liquid reactions. Applications to optimizing continuous pharmaceutical
applications in the real world will also be discussed.
Biography
Rocky C. Costello, P.E. is the president of R.C. Costello & Assoc.,
Inc. an engineering firm specializing in chemical process
engineering. They provide engineering design services to the
specialty chemical, chemical and pharmaceutical industries.
He obtained his Bachelor’s degree from Youngstown State
University in 1974 and did further graduate work in Chemical
Engineering at Manhattan College in the Bronx. He worked in
private industry prior to starting the engineering firm. At Owens-
Corning he worked in polymers and plastics, at Rhodia (Now
Solvay) he worked in specialty chemicals and pharmaceutical
intermediates. At Southdown environmental he was in charge
of the Mexican and Californian operations for the recycling
of waste solvents into pure solvents for reuse by fractional
distillationandthinfilmevaporation. Heholdsnumerouspatents
and has been published in a number of chemical engineering
publications. He is a licensed professional Chemical Engineer
in a number of states. His major interests include the design
of continuous pharmaceutical plants (Flow Chemistry) utilizing
unique unit operations such as the Spinning Tube in a Tube
(STT) reactor and the Fluxxion separator. A second interest
is the computer modeling and simulation of Flow Chemistry
processes utilizing ChemCad simulation software.
rcca@rccostello.comUtilizing the spinning tube in a tube
(STT®) reactor in flow chemistry
Rocky Costello
1
, Michael Gonzalez
2
and
David E Meyer
2
1
R C Costello & Assoc., Inc, Redondo Beach, California, USA
2
NRMRL, US EPA Office of Research and Development, MS
Cincinnati, Ohio, USA
Rocky Costello et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-007