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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 83
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
T
he thyroid injury is the most frequent organ specific autoimmune disease.
The thyroid gland is the target of two main autoimmune pathologies; Grave
disease (GD) and Hashimoto’s thyroiditis (HT). The autoimmune thyroiditis
(AIT) shares a common immunological marker, which is the presence of
circulating antithyroid antibodies (ATA). The type of these ATA and their
targets define the specificity of each disease. The objective of our study
was to determine the clinical significance of the ATA; thyroid pyroxidase
(TPOAb), thyroid globuline (TGAb) and the TSH-receptor antibodies (TRAb), in
thyroidal and non-thyroidal pathologies. We conducted a cross-sectional and
retrospective study on patients having positive antithyroid antibodies enrolled
at the laboratory of immunology of the University Hospital of Marrakesh during
the period from January 2014 to January 2016. The mean age of our patients
was 38±16 years with a sex-ratio M/F of 0.57. The ATA were associated in
70.9% of cases to hypothyroidism, in 22.15% to hyperthyroidism and in 7 %
of cases to euthyroidism. The hypothyroidism was noted in 83.2% of TPO Ab
positive cases, the hyperthyroidism in 87.2% of TRAb positive cases and the
euthyroidism in 6.4 % of TPOAb positive ones. Thyroiditis were represented
essentially by the HT, noticed in 110 patients (69.6%) and the GD in 37 (23.4%).
ATA were associated to non-thyroidal autoimmune diseases in 29.7% of cases
specially represented by type 1 diabetes, sjogren syndrome, celiac disease,
lupus and the PBC, associated to TPOAb in (10.4% ), (4.8%) ,(4 %), (3.2 %)
and (3.2%). The autoimmune polyendocrinopathy was associated with TRAb
in 7.7 % and TPOAb in 1.6% of cases. These ATA were also associated to
non-thyroidal and non-autoimmune pathologies such as type 2 diabetes and
hypertension which were especially associated to the TPOAb in 5.6 % and 4
% respectively followed by Turner’s syndrome and Crohn’s disease who were
especially associated to TGAb in 6.25 % for each one. The results objectified in
our series suit generally to various series of literature. These results underline
the importance of ATA in clinical practice especially in thyroidal and/or non-
autoimmune pathologies and required a finical interpretation to establish
exactly their real clinical significance and to help for better medical care of
patients.
Clinical significance of antithyroid antibodies
Dounya Bounid
1
, Mourad Chaqraoui
1
, Lahcen Elmoumou
2
and
Brahim Admou
1
1
Cadi ayyad university, Morocco
2
Mohammed VI university hospital, Morocco
Dounya Bounid et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003
Biography
Dounya Bounid (MD) has completed his Medical Studies
from School of Medicine, Cadi Ayyad University (Marrakech,
Morocco) and actually Resident in Medical Biology (second
year) in the same university.
dounia.bounid@gmail.com