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Volume 4 Trends in Green Chemistry
ISSN: 2471-9889
Page 83
JOINT EVENT
Environmental Chemistry 2018 &
Green Technologies 2018
September 20-22, 2018
September 20-22, 2018 Berlin, Germany
&
7th Edition of International Conference on
Green Energy, Green Engineering and Technology
8th International Conference on Environmental Chemistry and Engineering
Decreasing the synthesis reaction time and toxicity of biologically active hetero (N-, P- and F-) organics
using green chemistry
Olzhas Akhmetsadyk, Kaldybay Praliyev, Gulzeinep Begimova, Alexey Zazybin and Valentina Yu
Kazakh-British Technical University, Kazakhstan
S timulation of immunity of living organisms (immunocorrection) allows inducing their complex nonspecific resistance to
many diseases of fungal, bacterial and viral origin, furthermore toother unfavorable environmental factors. For the purpose of
synthetic search of potential immunocorrectors, we have synthesized new α-aminophosphonates based on 1-phenylpiperazine
and 1-benzhydrylpiperidine using classical Kabachnik-Fields reaction conditions. Weak sides of the procedure used for their
preparation is the reaction time-24 and more hours and as use of benzene. It turned out that microwave radiation, as expected,
significantly reduces the reaction time to 15-25 min. To obtain the target α-aminophosphonates, 15 min microwave radiation
is most effective using BMIB. The effect of magnesium oxide on the reaction with 1-phenylpiperazine is well noticed. The
catalytic activity of oxides of magnesium and zinc on formation of the target α-aminophosphonates under 25 min microwave
irradiation is shown. The lower yields of the products of benzhydryl derivatives, both in classical and microwave conditions,
can be explained by the steric hindrance created by the benzhydryl group. In addition, microwave radiation lets to exclude
use of benzene from the synthesis. The anesthetic properties and toxicity level were studied at National Medicinal University,
in Almaty, Kazakhstan. These studies showed that synthesized organics have superior lethal dose concentration, higher
anesthesia index and more effective infiltration and conductive anesthesia parameters when compared to known marketed
local anesthetics.
Scheme for the Kabachnik-Field reaction for the synthesis of α-aminophosphonates
Recent Publications
1. Begimova G U, Akhmetsadyk О E, Praliyev K D and Yu V K (2016) Dimethyl[(3,4-dimethoxyphenyl)
(4-phenylpiperazine-1-yl)methyl]phosphate: synthesis and structure // Chemical Journal of Kazakhstan 1:179-184.
Biography
Olzhas Akhmetsadyk has completed his Graduation at Middle East Technical University in Ankara, Turkey. He is working as a Head of Medical Devices Testing
Laboratory of National Center for Expertise of Medicines and Medical Devices, Ministry of Healthcare of Republic of Kazakhstan. His recent duties as a Medical
Devices Regulator are to evaluate the quality management system of manufacturers upon registering their products in Kazakhstan and to assess the quality of the
products according to quality specifications. His research interests include synthesis of bio-active (P-, N- and F-) heterocycles, β-cyclodextrin complexes with bio-
active substances, NMR and X-ray studies of cyclodextrin complexes, biocompatibility of cyclodextrin complexes and microbial activity of cyclodextrin complexes.
Olzhas Akhmetsadyk et al., Trends in Green chem 2018, Volume 4
DOI: 10.21767/2471-9889-C2-012