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E u r o S c i C o n C o n f e r e n c e o n
Dental & Dental
Hygiene
Dental & Dental Hygiene 2018
Journal of Dental and Craniofacial Research
ISSN 2576-392X
M a r c h 2 6 - 2 7 , 2 0 1 8
E d i n b u r g h , S c o t l a n d
Page 57
Background:
Oral candidiasis is a mycosis (yeast/fungal infection) of Candida
species on the mucous membranes of the mouth. Humeral immune response
to candidal infection has much theory according to site of infectionmediated by
T-helper maturation, differentiation and secretion of cytokines. Interleukin-33
is one of the IL-1 super families which are called alarming cytokines family as
they inform the immune system about any tissue injury, infection or necrosis.
IL-33 is multifunctional cytokines that has anti-inflammatory (protective),
inflammatory effect on tissue by modulating the action of T-Helper17.
Aim of study:
To study the effect of InterLeukin-33 on T-Helper 17 cytokines
InterLeukin-17 and InterLeukin-22 in saliva of patients with oropharyngeal
candidiasis before and after therapy with Nystatine in comparison to control.
Materials & Methods:
forty patients visiting AL-Yarmouk teaching hospital
/Baghdad were included in this study having clinical symptoms of oral
candidiasis and after a positive confirmation of infection using slandered
mycological techniques and identification to species using smearing methods
and swab culturing on chromagar media, saliva samples were collected from
them between 8:00 and 11:00 am and centrifuged and stored at -60 c0 until
immunological analysis using ELISA kits.
Results:
there are a significant difference inmedian Of IL-17 in saliva of patients
and control were respectively (85.4, 440.4), (p<0.001). Median value of IL-22
was higher in patients than control group was respectively (429.9, 38.3) and
the difference was statistically significant with p 0.003. IL-33 median value in
control group was lower than patient group were (227, 2 – 585, 2)
Effect of interleukin-33 on T-Helper17 cytokines
InterleukinL-17 and InterLeukin-22 in saliva of patients with
oropharyngeal candidiasis
Wifaq M.Ali Al-Wattar
1
, Warkaa
M.Al-Wattar
2
, Maher K.Jasim
3
and Jamal N.Ahmed
4
1
Assistant Prof. College of medicine, University of Baghdad,college of medicine,Unit of clinical
and communicable diseases (MBCHB. MSc , FICMS)
2
Lecturer in Oral Pathology department, College of Dentistry, Mystansiriyah University-Depart-
ment of Oral pathology..
3
College of Dentistry, Baghdad University
4
Professor ,Department of Oral Diagnosis, College of Dentistry, Baghdad University.
Warkaa
M.Al-Wattar et al., J Den Craniofac Res 2018, Volume: 3
DOI: 10.21767/2576-392X-C1-003
Biography
Warkaa
M.Al-Wattar is a Lecturer in Oral Pathology department,
College of Dentistry, Mystansiriyah University-Department of
Oral pathology.
wifaqalwatar@rocketmail.comrespectively
and
statistically
significant p value (<0.001). There are
a great reduction in IL-17 and IL-22
after treatment with a median value
of (-278.9, -134.35) respectively. At
the same time IL-33 concentration
elevated after therapy and the
difference was (203.35)
Conclusion:
IL-33 has local protective
effect (anti-inflammatory) on mucosa
by decreasing the secretion of IL-17
and IL-22 in saliva of patients with
oropharyngeal candidiasis and so
reduces tissue damage caused by
excessive immune response.