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E u r o S c i C o n C o n f e r e n c e o n
Dental & Dental
Hygiene
Dental & Dental Hygiene 2018
Journal of Dental and Craniofacial Research
ISSN 2576-392X
M a r c h 2 6 - 2 7 , 2 0 1 8
E d i n b u r g h , S c o t l a n d
Page 53
F
ive-fluorouracil (5-FU) is an antimetabolite drug used in the treatment of
various cancers, including basal cell carcinomas (BCC). Some authors
believe that odontogenic keratocyst (OKC) would respond to 5-FU treatment
because of their similarities to BCCs in molecular etiopathogenesis. The
odontogenic keratocyst (OKC) is a developmental odontogenic cyst that arises
from remnants of the dental lamina. A case of an OKC treated with 5-FU is
presented in this study. A brown-skinned male, 61-year-old, sought an Oral
and Maxillofacial Surgery service. During the clinical examination no mucosal
changes, bone expansion or face asymmetry were observed. A panoramic
radiography was performed and a unilocular radiolucent lesion was verified in
the body and ascendingmandibular ramus. The extraction of #17 and incisional
biopsy were performed, and the diagnosis established was OKC, according
to the histopathological patterns. Therefore, it was decided to perform a
marsupialization and 5-FU intralesional. As a result, it could be observed
exuberant bone neoformation, mainly in the basilar region of the mandible.
Follow-up examination 4 months later showed no evidence of recurrence and
the patient will be followed for at least another year so we can decide if another
surgical procedure is necessary.
Five-fluouracil for odontogenic keratocyst treatment: a case
report
Giulianna Lima Pinheiro, Nathália Almeida, Ana Lucia Miceli, Cesar Noce, Erika
Kuzsminszky, Gabriel Quintanilha and Beatriz Venturi
Rio de Janeiro State University, Brazil
Giulianna Lima Pinheiro et al., J Den Craniofac Res 2018, Volume: 3
DOI: 10.21767/2576-392X-C1-003
Biography
Giulianna Lima Pinheiro is a student at Dentistry College, Rio de
Janeiro State University, Brazil. She is also an intern at Galeão's
Air Force Hospital and a Teaching Assistant at Dentistry College
(Oral Diagnosis).
giuliannal@gmail.com