chronic-diseases-2017-scientifictracks-abstracts

6 / 22

Notes:
Volume 2, Issue 2 (Suppl) Chronic Obstructive Pulmonary Diseases
ISSN: 2572-5548
Page 24
conferenceseries.com
CO-ORGANIZED EVENT
August 31-September 01, 2017 Brussels, Belgium
&
International Conference on Chronic Diseases
6th International Conference on Microbial Physiology and Genomics
Human herpes virus type 8 in patients with cirrhosis
Cheng-Chuan Su1,2
1Tzu Chi University, Taiwan
2Dalin Tzu Chi Hospital, Taiwan
To date, human herpesvirus type 8 (HHV-8) DNA has been found consistently in all types of Kaposi’s sarcoma (KS). This
neoplasmoccasionally develops in human immunodeficiency virus (HIV) non-infected patients with variable immunologic
abnormalities. Immunologic abnormalities have been documented in cirrhotic patients and are strongly associated with
cirrhosis severity. In a previous study, our study group found that the seroprevalence of HHV-8 in patients with moderate or
severe cirrhosis was significantly greater than that in healthy controls. It appeared to be associated with cirrhosis severity, sex,
and disease etiologies. However, the prevalence of HHV-8 infection in patients with mild cirrhosis has not been described,
and it is not clear whether HHV-8 prevalence is associated with hepatitis activity. Our recent study found that patients with
mild cirrhosis had higher seropositivity for KSHV antibodies than healthy controls (P=0.0001). Univariate logistic regression
analysis revealed that an age≥55 years (odds ratio [OR] 2.88, P=0.02), hepatitis C virus (HCV) infection (OR 3.42, P=0.01), and
hepatitis activity (OR 4.10, P=0.004) were associated with KSHV seropositivity in mild cirrhotic. Stepwise multivariate logistic
regression analysis confirmed that age≥55 years (adjusted OR [aOR] 1.92, P=0.04) and hepatitis activity (aOR 3.55, P=0.005)
were independent factors. The rate of hepatitis activity was higher in HCV-infected than in HBV-infected patients (P<0.0001)
and in women than in men (P=0.0001). Mild cirrhotic who were seropositive for KSHV or HCV or had hepatitis activity were
significantly older (P=0.02, <0.0001, and <0.0001, respectively). Plasma samples from all participants were negative for KSHV
DNA. KSHV antibody titers in mild cirrhotics also markedly exceeded those in controls (P<0.0001), as in patients≥55 years
old vs. younger patients (P=0.01), those in patients with vs. without HCV-infection (P=0.0008), and those in patients with vs.
without hepatitis activity (P=0.0005). Patients with mild cirrhosis had high KSHV seroprevalence and HCV infection, and, in
particular, old age and hepatitis activity were predictors.
Biography
Cheng-Chuan Su has completed residency training in Anatomic Pathology at the age of 31 years and in Clinical Pathology two years later; and obtained the Master
degree from the Institute of Biomedical Engineering, National Cheng Kung University, Taiwan when he was 32 years old. At present, he is the Medical Director
of Department of Clinical Pathology and the Attending Physician of Department of Anatomic Pathology, Buddhist Dalin Tzu Chi Hospital, and the Professor of
Departments of Laboratory Medicine and Pathology, Tzu Chi University, Taiwan. He has published more than 40 papers in reputed journals and has been serving
as an editorial board member of reputed journals.
Cheng-Chuan Su, Chron Obstruct Pulmon Dis 2017, 2:2
DOI: 10.21767/2572-5548-C1-002