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Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
Chemistry
F e b r u a r y 1 9 - 2 0 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
Chemistry 2019
2 n d E d i t i o n o f E u r o S c i C o n C o n f e r e n c e o n
Oxazole is a structural motif in huge number of natural products and
biologically active compounds. Among the numerous procedures reported
for the synthesis of substituted oxazoles, cycloisomerization of propargylic
amides to substituted oxazoles has attracted much attention. On the other
hand, the one-pot synthesis of substituted oxazoles directly from propargylic
alcohols and amides via propargylic amides as intermediates remains a
challenging task, although both propargylic substitution and subsequent
cycloisomerozation might proceed effectively under the same reaction
conditions. Herein, we present the one-pot synthesis of substituted oxazoles
by gold-catalyzed propargylic substitution followed by cycloisomerization
promoted by β-cation-stabilizing effect of the silicon atom of 3-trimethylsilyl
propargylic alcohols.
Biography
Nobuyoshi Morita was born in Iruma, Saitama, Japan in
1973. He received his B.S. degree from Meiji Pharmaceutical
University (Prof. Dr. Masanori Sakamoto) in 1997 and his Ph. D.
degree from Osaka University (Prof. Dr. Yasuyuki Kita) in 2003.
After three years (2003-2006) postdoctoral work at Dortmund
University of Technology in Germany (Prof. Dr. Norbert Krause),
he was then recruited as Assistant Professor of organic
chemistry in Showa Pharmaceutical University (Prof. Dr. Osamu
Tamura) in 2006 and became an Associate Professor of
organic chemistry in Showa Pharmaceutical University in
2016.
Gold-catalyzed one-pot synthesis of substituted oxazoles
from 3-trimethylsilyl propargylic alcohols and amides
Nobuyoshi Morita
Showa Pharmaceutical University, Japan
Nobuyoshi Morita, J Org Inorg Chem 2019, Volume: 5
DOI: 10.21767/2472-1123-C1-020