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E u r o S c i C o n C o n f e r e n c e o n
Chemistry
2018
Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
F e b r u a r y 1 9 - 2 0 , 2 0 1 8
P a r i s , F r a n c e
Page 64
T
he present study reports the chemotypic variability
of bioactive alkaloids (colchicine and gloriosine) and
phenolics (quercetin and kaempferol) through calibrated
HPTLC method in G. superba L. (tuber), collected from 17
location of Central India and Gangetic plains. The effect of
phytogeography on their antioxidant and anti-inflammatory
Impact of geographical
variation on chemotypic
variability and
biological potential
of Gloriosa superba L.
collected from central
india and gangetic
plains (india).
Ankita Misra
1,2
, Sharad Sri-
vastava
1
, Poonam Kushwaha
2
and Pawan Kumar Agrawal
3
1
Pharmacognosy and Ethnopharmacology
Division, CSIR-National Botanical Research
Institute, Lucknow (U.P.), 226001, India
2
Department of Pharmacy, Integral University,
Lucknow (U.P), 226001, India
3
National Agriculture Science Fund, New Delhi,
India
potential was also established. Quantification data reveals that
the content of colchicine (COL) and gloriosine (GLO) varies
from 0.02 – 0.513% and 0.028 – 0.165% respectively. Maximum
content of colchicine and gloriosine was reported in NBG-10
(Kanth, U.P) and NBG- 11 (Mohanlalganj, U.P) having 0.513
and 0.165%. Quercetin and kaempferol content varies from
0.0007 to 0.122 % and 0.005 to 0.075 %, maximum is reported
in NBG-13 (Bheragha, M.P) germplasm. The investigated
test extract showed promising antioxidant activity which was
found in significant correlation to total phenolic and flavonoid
contents. Although varied results were observed against invitro
anti inflammatory activity, the best results was observed in
NBG-01 (0.0038 %) whereas lowest activity was observed
in NBG-78 (0.0117 %). Based on statistical evaluation on
quantative analysis of bioactive metabolites and bioactivity five
germplasm were identified as elite chemotypes of G. superba
(NBG-1, NBG-10, NBG-11and NBG-13) in the targeted phyto-
geography. Furthermore our study proves significant variability
in biological potential of G. superba extract with the change
in phytogeographical content. Thus, it will aid in site specific
exploration of high metabolite yielding chemotype(s) with
validated pharmacological action to meet out the medicinal and
commercial demands.
anku.mis@gmail.comJ Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C1-003