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Case Reports 2018 Medical Case Reports
ISSN: 2471-8041 Page 24
May 28-29, 2018
London, UK
8th Edition of International Conference on
Clinical and Medical Case Reports
T he achievement of a successful pregnancy after oocyte
activation with calcium ionophore is reported in a couple
having low fertilization rates after intracytoplasmic sperm
injection (ICSI) of in-vitro matured oocytes. A couple, in which
the wife is 41years old, who had polycystic ovary syndrome and
the husband is 48, who had moderate oligoteratozoospermia,
showed a low implantation rate in previous 5 cycles. In the
latest cycle, 2 inmature oocytes were retrieved. 24h later,
artificial oocyte activation by calcium ionophore was combined
with ICSI to achieve viable fertilized oocytes. Oocytes were
stimulated with calcium ionophore for 15 min after ICSI. On the
fifth day, two blastcycsts were formed and frozen. Two months
later, two blastcycsts derived from the activated oocytes
were transferred into the uterus after thawed. Subsequently,
one gestational sac was identified on ultrasound. This result
suggests that calcium ionophore could be useful for aged
patients with low fertility after ICSI of in-vitro matured oocytes.
Figure 1: Gestational sac in the picture is marked with a red arrow
Biography
Dr.Mingrong completed her PhD fromUniversity of Science and Technology
of China in 2015. She has published more than 6 papers in Cell Death and
Disease , Scientific reports and so on. Now she works in the Reproductive
Medicine Center, Department of Obstetrics and Gynecology, The First Affili-
ated Hospital of Anhui Medical University, Hefei, China.
Successful pregnancy after ICSI with artificial oocyte
activation by calcium ionophore in in-vitro matured oocytes for
a women of advanced age : a case report
Mingrong lv1, Zhiguo zhang2 and Yunxia cao1,2,3
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated
Hospital of Anhui Medical University,China
2Province Key Laboratory of Reproductive Health and Genetics, AHMU,China
3Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial
Organs,China
Mingrong lv, Med Case Rep. 2018, Volume 4
DOI:10.21767/2471-8041-C1-002