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Neurosurg, an open access journal
ISSN: 2471-9633
Page 15
Notes:
August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4th International Conference on
alliedacademies
Background: Alzheimer’s disease (AD) is the most common
cause of dementia where symptoms gradually worsen over
a number of years. Social isolation exacerbates memory
loss while mental and physical activities training can help in
maintaining cognitive functions. Epigallocatechin-3-gallate
(EGCG) is a natural chelator with health-promoting effects
in CNS and wheat grass is a natural antioxidant and has high
ability to counteract free radicals. Objective: To study the
combined effects of EGCG and wheat grass together with
mental and physical activities against induction of AD as well
as to compare between their combined effects in socialized
and isolated conditions.
Methods: Eight groups of rats (4 socialized and 4 isolated)
were exposed to both Swimming test and Y-maze (each
for one time/week) for maintaining mental and physical
activities. Two groups of socialized as well as of isolated
rats were normal rats while the others were AD rat's model
(received daily 70mg/kg AlCl3, IP). During the four weeks
of the experiment, normal and AD rats in either isolated
or socialized condtions received either saline for control or
EGCG (10mg/kg every other day IP) & wheat grass (100mg/
kg PO daily) for treated groups. Cages covered with black
plastic were used for social isolation. Changes in brain Aβ,
ACHE, monoamins, inflammatory mediators, oxidative
parameters as well as brain derived neurotrophic factor
(BDNF) were measured for all groups. Histopathological
changes in different brain regions were also detected.
Results: Brain neurological damage characterizing isolation
and/or AD were more severe in isolation-associated AD
group. EGCG and wheat grass together with mental and
physical activities showed higher protection against hazards
of AlCl3 or isolation than mental & physical activities alone
especially in isolation-associated AD group. Their protection
was indicated by the significant decrease in Aβ, ACHE, MDA,
TNF-α, IL-1β together with the increase in SOD, TAC, brain
monoamins, BDNF and confirmed by histopathological
examinations.
Conclusion: EGCG and wheat grass together with mental
and physical activities has more pronounced protective
effect against brain neuronal degenerations associated the
development of AD especially in social isolation conditions
than mental and physical activities alone.
Key words: Alzheimer’s disease; Epigallocatechin-3-gallate;
Wheat grass; Mental and physical activities; Social isolation;
Rats.
Speaker Biography
Prof. Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology
from Faculty of Pharmacy, Cairo University. Her postdoctoral studies included differ-
ent scientific aspects related to her specialization field with giving especial interest
to researches of neuropharmacology and psychopharmacology; she also developed
research line of behavioral pharmacology in Egypt. She is member of many scientif-
ic societies in Egypt and of (AAPS) American Association of Pharmaceutical Scientists
(2002) and published more than 35 papers in reputed journals, supervised and dis-
cussed more than 50 PhD and MSc thesis and actively participated by oral and posters
presentations at many international conferences especially on Alzheimers disease &
Dementia. Now she is a Head of Pharmacology and Toxicology Department at Al-Azhar
University and she sacrifices great effort hoping to find real treatment that can prevent
or delay the progression of Alzheimers disease especially in the high-risk individuals
focusing on depression, stress and malnutrition.
e:
Azza A Ali
Al-Azhar University, Egypt
The Possible Interaction between the Influence of Epigallocatechin-3-gallate and
Wheat Grass Together with Mental and Physical Activities against Alzheimer’s disease
in Isolated and Socialized Rats
Azza A Ali, Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-004