36 / 39
Notes:
Volume 3, Issue 2
Insights in Analytical Electrochemistry
ISSN: 2470-9867
Analytical Chemistry-Formulation 2017
August 28-30, 2017
Page 58
8
th
Annual Congress on
&
14
th
International Conference and Exhibition on
August 28-30, 2017 Brussels, Belgium
Analytical and Bioanalytical Techniques
Pharmaceutical Formulations
A I Archakov et al., Insights in Analytical Electrochemistry, 3:2
DOI: 10.21767/2470-9867-C1-002
Molar concentration welcomes Avogadro in postgenomic analytics
A I Archakov, A V Lisitsa
and
E A Ponomarenko
Institute of Biomedical Chemistry, Russian Federation
T
he researchers working with high-throughput methods of genomics, transcriptomics, and proteomics reconsider the
concept of concentration and evaluate the data obtained in the number of copies of biomacromolecules. Measurement
of copy number reflects a steady trend in increasing the sensitivity of postgenomic analytical methods, up to the level of a
single molecule. In this paper we review the physical meaning of the terms "molar concentration" and "Avogadro’s number"
to establish a relationship between them. The relationship between the molar concentration and the number of copies of
that same macromolecule in a certain volume is set through the reverse Avogadro’s number, the value of which (≈10-24
М) characterizes the molar concentration of a single molecule in 1 liter. Using the reverse Avogadro’s number, we deal with
situations in analyzing homogeneous biological solutions and heterogeneous cellular material.
inst@ibmc.msk.ru