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December 06-07 , 2018
Amsterdam, Nether l ands
Journal of Neuropsychiatry
ISSN: 2471-8548
Alzheimer’s and Dementia 2018
1 3
t h
W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
M
ethylphenidate (MPD) is widely prescribed drug for the treatment of attention deficit hyperactivity disorder (ADHD). Despite
its therapeutic importance, there is growing evidence that patients treated with MPD develop an addiction to their therapy.
The drug is also used as a cognitive enhancer to improve academic performances. It is therefore important to monitor abuse
potential of clinically useful doses of MPD and molecular mechanism associated with its cognition enhancing and reinforcing
effect. The present study is designed to study abuse potential, if any, of clinically relevant doses of MPD. The levels of dopamine
(DA), dihydroxphenyl acetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (5-HT), 5-hydroxyindole acetic acid (5-
HIAA), and noradrenaline-hydrochloride (NA-HCl) are monitored in the hippocampus and caudate. In view of role of 5HT-1A
receptor in cognition as well as addiction, the expression of 5-HT1A receptors in the prefrontal cortex and nucleus accumbens
is monitored in rats repeatedly treated with MPD. We report that lower doses (0.5 and 2.5 mg/kg) of MPD enhance learning
acquisition and memory retention in a dose dependent manner in Morris water-maze test. Higher dose (5 mg/kg) of MPD however
impairs these. The drug administered repeatedly at dose of 2.5 mg/kg is reinforcing in conditioned place preference paradigm.
Sensitization like effect produced transient and are not consistently shown. Result shows an increase in 5-HT metabolism in the
hippocampus as well as caudate. Effects of DA metabolism are not consistent. HVA levels are decrease markedly in hippocampus
but are increases in the caudate. The expression of 5HT-1A receptor attenuated markedly in the nucleus accumbens, but no effect
on 5HT-1A receptor occurs in the prefrontal cortex. The results strengthen our previous studies of a role of 5HT-1A receptors in
addiction. The findings may be of use in improving therapeutics in ADHD and developing non addictive cognitive enhancers.
tabinda.salman89@gmail.com,
ceap@nays.com.pkNeurochemical, behavioural and molecular level
studies of methylphendiate in rats
Tabinda Salman and Darakhshan J Haleem
PCMD-ICCBS, University of Karachi, Pakistan
J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-003