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December 06-07 , 2018
Amsterdam, Nether l ands
Journal of Neuropsychiatry
ISSN: 2471-8548
Alzheimer’s and Dementia 2018
1 3
t h
W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
H
uman neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are recognized clinically
by dementia in aging populations. They are characterized by enhancement in oxidative stress and reduction in antioxidant
defence mechanisms in neurons that result ultimately in neuronal death. Prevailing FDA approved drugs cannot cure or stop
the progression of the disease. These drugs also cause many undesirable side effects. Since PD is a relentless disease without
a cure, the need of the hour for these patients is to provide palliative care. Several promising drugs are being screened and
the quest for discovery of new drugs continues. Drosophila serves as an ideal organism for high throughput screening of
drugs due to possibility of generating neurodegenerative disease model and the rescue achieved by administrating potential
drug. Epidemiological data suggests that phytochemicals can protect the nervous system against degeneration. Based on the
cytoprotective and neuroprotective properties of the extract from edible roots of
Decalepis hamiltonii
(Dh) in mammalian model
and cells in culture, we investigated the neuroprotective potential of the extract by employing A30P and A53T α-synuclein PD
model of
Drosophila melanogaster
. The study revealed improvement in climbing ability, circadian rhythm of locomotor activity,
antioxidant defences, protection against paraquat sensitivity and delay in the onset of PD like symptoms in Dh fed transgenic
flies. In a separate line of investigations on
D. melanogaster
, we found that
Dh
feeding markedly enhances cognitive ability of aged
flies and their offspring. To extend our investigations, we created transgenic human apolipoprotein E model of neurodegenerative
disease to characterize and work with Dh. With the desirable properties, we foresee that the Dh cocktail could be a promising elixir
of natural origin that can improve the life of patients suffering from neurodegeneration.
rameshuom@gmail.com rameshsr.fgc@mahajana.edu.inNeuroprotective potential of
Decalepis hamiltonii
:
A study with transgenic A30P and A53T
α
-synuclein
Parkinson disease model of
Drosophila melanogaster
S R Ramesh, Samaneh Reiszadeh Jahromi, Mohammad
Haddadi and T Shivanandappa
University of Mysore, India
J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-003