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Alzheimer’s and Dementia
Journal of Neuropsychiatry
ISSN: 2471-8548
December 06-07 , 2018
Amsterdam, Nether l ands
Alzheimer’s and Dementia 2018
Page 16
A
lzheimer’s disease (AD) is the most common neurodegenerative disorder
which is characterized by impairment of cognitive function. Thioredoxin-1
(Trx-1) is a redox regulating protein, has antioxidant and protecting neuron effects.
Our previous study found that Trx-1 improved the cognitive function of Parkinson’s
disease (PD) mice. However, whether Trx-1 improves the cognitive function of AD
is still unknown. In present study, APP/PS1 transgenic mice model were used.
Trx-1 overexpressed transgenic mice were hybridizing with APP/PS1 transgenic
mice. Our results showed that the escape latency in APP/PS1 transgenic mice
was longer when compared with the control group, which was reduced in Trx-1/
APP/PS transgenic mice significantly by using the navigational experiments in
Morris water maze. In the spatial probe test, the total number of crossings and
the percentage of time spent in the target quadrant were decreased in APP/
PS1 transgenic mice, which were significantly increased in Trx-1/APP/PS mice.
The mRNA levels of APP and PS1 were decreased in Trx-1/APP/PS1 mice when
compared to APP/PS1 mice. These results suggest that Trx-1 improves cognitive
function of APP/PS1 mice. Trx-1 may be a potential therapeutic target for the
clinical management of AD.
Thioredoxin-1 improves the cognitive
function of APP/PS1 mice
Jie Bai, Liping Bai, Ye Li, Xianwen Zhang,
Xiaoshuang Zhou and Cheng Yan
Kunming University of Science and Technology, China
Jie Bai et al., J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-001
Biography
Jie Bai has completed her PhD from Kyoto University and
Postdoctoral Studies from Health Center, University of Virginia.
She is the Professor of Kunming University of Science and
Technology, China. She has published more than 50 papers in
reputed journals.
jiebai662001@126.com