3 / 4
1 3
t h
W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
Journal of Neuropsychiatry
ISSN: 2471-8548
December 06-07 , 2018
Amsterdam, Nether l ands
Alzheimer’s and Dementia 2018
Page 15
A
lzheimer’s disease (AD) is a major cause of dementia. Major risk factors that
can predispose a person to AD include aging, traumatic brain injury (TBI) and
the presence of ApoE4 allele. All risk factors involve progression to memory loss
due to continuous neurodegeneration causing inflammation. Aging, a major risk
factor for ADcan result in hypertension, vascular dementia, diabetic complications,
coronary
hear
t disease etc., which can all contribute to AD. TBI can set in motion
to continuous inflammation in the brain. The presence of ApoE4 allele can be
detected by isolating genomic DNA from saliva and determining single nucleotide
polymorphism in ApoE gene. If ApoE4 allele is found there can be a three-four
fold higher predisposition to AD compared to ApoE2 or ApoE3. One of the harmful
effects of the ApoE4 allele is the harmful neurodegeneration due to inflammation.
Vaccinia virus complement control protein has been shown to control compliment
levels in the brain and could contribute to slowing the progression of AD along
with life style and nutritional changes that could result in weight, glucose and lipid
control.
Strategy for controlling brain inflammation
due to aging, head trauma and genetic
predisposition of Alzheimer’s disease
Girish J Kotwal
School of Medicine, University of Massachusetts, USA
InFlaMed Inc, USA
Kotwal Bioconsulting LLC, USA
Noveratech LLC, USA
Girish J Kotwal, J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-001
Biography
Girish Kotwal has completed his PhD fromMcMaster University,
Canada and Postdoctoral Studies from National Institutes of
Health, Bethesda, USA. He is an Adjunct Professor of Medicine
at UMass Medical School, President at InFlaMed and Kotwal
bioconsulting, LLC and Senior Scientist at Noveratech LLC. He
has published more than 100 PubMed listed papers in reputed
journals and has been serving as an Editorial Board Member of
repute. Over a 30-year period beginning in 1988 with a report in
the journal
Nature
, he began research on a complement control
protein and showed that regulating complement activity in
several CNS conditions could be potentially beneficial.
GJKOTW01@gmail.com