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Advanced Stem Cell 2018 Journal of Stem Cell Biology and Transplantation
ISSN: 2575-7725 Page 22
December 03-04, 2018
Valencia, Spain
15th Edition of EuroSciCon Conference on
Advanced Stem Cell &
Regenerative Medicine
Currently, stem cells and their applications in the clinic
has triggered a great interest in the field of regenerative
medicine. However, there are still many challenges that
are awaiting a definitive solution, like scarcity of stem cell
availability on a large scale, difficulty in controlling stem
cell fate once reintroduced inside the body and their guided
delivery to the site of injury. In this regard, recent technological
advancements and scientific achievements in cellular
reprogramming to produce induced pluripotent stem cells for
more readily accessible and versatile cell types are a potentially
very important breakthrough. However, the transgenic approach
in such reprogramming has raised serious concerns related to
safety, efficacy and feasibility of the applications and hence a
complementary approach needs to be identified. In this regard,
small molecule based reprogramming involving defined
signaling pathways and significant epigenetic processes offers
powerful options for guided cellular trans-differentiation,
manipulation of cellular fate and speedy reprogramming.
This review is intended to discuss the applications of small
molecules (pharmaceutical type chemicals) in promoting
pluripotency. We also highlight the recent progress in a variety
of applications of iPSCs (induced pluripotent stem cells) such
as drug screening, disease modelling, toxicity analysis, etc.
Biography
Ila Tewari pursued her Master’s Degree as a Microbiologist at Amity Univer-
sity, India. Later on she worked in a stemcell based industry on Autologuous
and Allogenic blood transplant XXXXXX and then started working at Univer-
sity of Malta as PhD student as well as Research Support Officer II where,
she has continued her research. Currently, she is working in Department of
Anatomy, Faculty of Medicine and Surgery at University of Malta.
Review on chemical generated pluripotency of
stem cells and its applications
Ila Tewari, Simona Pagano and Pierre Schembri Wismayer
University of Malta, Italy
Ila Tewari et al., J Stem Cell Biol Transplant 2018, Volume 2
DOI: 10.21767/2575-7725-C1-002