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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Notes:
JOINT EVENT
October 04-05, 2018 Moscow, Russia
&
2nd Edition of International Conference on
26th International Conference on Advanced Nanotechnology
Materials Technology and Manufacturing Innovations
Advanced Nanotechnology 2018
& Materials-Manufacturing 2018
October 04-05, 2018 Page 23
Elazar Y Gutmanas
Technion-Israel Institute of Technology, Israel
Elazar Y Gutmanas, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C5-020
Biodegradable load-bearing nanocomposites for controlled drug delivery and damaged
bone repair
The requirement for new bone to replace or restore the function of damaged or lost bone, including cases of
tumor resection, is a major clinical and socioeconomic need. Bone grafting is intended to stimulate bone
healing and fill bone defects. Load-bearing ability of grafts is very important to avoid additional surgery, needed
if implant fixation and fasteners are used and should be removed. One of the research strategies in last years is
development of biodegradable graft substitutes. Biodegradable implantable devices should slowly degrade over
time and disappear with ingrown natural bone replacing the synthetic graft. Finally no foreign material is left
behind, allowing complete tissue regeneration without the risk of chronic inflammation or long term immune
response and stress shielding related bone atrophy. We present a short review on processing and properties,
including in vitro degradation, of load bearing biodegradable nanocomposites and of macroporous 3D scaffolds for
bone ingrowth. Nanostructuring of biodegradable β-TCP-polymer, β -TCP-metal, Fe-Ag and Fe-Fe2O3 composites
is achieved employing high energy attrition milling of powder blends, followed by high pressure consolidation
at ambient temperature and densities close to theoretical retention of nanoscale structure. The strength of
developed nanocomposites is significantly higher as compared with micronscale composites of the same or similar
composition. The developed nanocomposites supported the attachment the human osteoblast cells and exhibited
no signs of cytotoxicity. Interconnected system of nanopores formed during processing of nanocomposites is used
for incorporation of drugs, including antibiotics and anticancer drugs and can be used for loading of bioactive
molecules enhancing bone ingrowth.
Biography
Elazar Y Gutmanas has completed his PhD at the Institute of Solid State Physics, Academy of Sciences of USSR in 1970. He immigrated from the
USSR and joined Technion in 1974. He investigated dislocation mobility and mechanisms of plastic deformation. He developed near-net shape pro-
cessing method-cold sintering/high pressure consolidation of powders at ambient temperature and together with Prof Irena Gotman; powder immer-
sion reaction assisted coating-PIRAC and reactive forging–processing of dense ceramic matrix composites employing pressure assisted exothermic
reactions. Currently cold sintering is used for processing of load-bearing bioresorbable nanocomposites for orthopedic implants.