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M a y 0 9 - 1 0 , 2 0 1 9
S t o c k h o l m , S w e d e n
Page 38
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Advanced Chemistry 2019
2
nd
European Congress on
Advanced Chemistry
T
he aim of our research is the formulation of methodology creation for practical application of the regulatory action of
endogenous (physiological) concentrations of separate amino acids or their pathogenetically justified compositions.
Changes in amino acid pool in liquids and their tissues fund of oncology patients specifically characterize development of
cancer and largely induced by metabolic competition between the tumor and the tumor carrier. Correction of the intermediate
metabolic changes in cancer can be reached by the use of certain amino acids or their combinations. Based on the positions
of metabolomics, the free amino acid pool in biological fluids and tissues is regarded as a single information unit which is a
kind of “a chemical projection” of the genome. The proteome realized through this approach not only develops ideas about
the pool of amino acids as a dynamical system-generated supply of them from outside, but also due to endogenous synthesis,
transport, degradation and excretion and allows the identification of “key points” in intermediate metabolic equilibrium shift that
may reflect ratios at the individual levels of endogenous amino acids and related species (metabolically-related) compounds to
achieve “metabolic comfort.” On the basis of the experimental data, we suggest that the differences discovered in certain amino
acids concentrations in fluids and tissues are the criteria in early diagnostics as in estimation of the efficacy of specific cancer
treatment. Our clinical studies on biological fluids and tumours of more than 1400 patients with cancer depending on the location
and stage of the process showed significant changes in physiological concentrations of amino acids which either directly or
indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. The creation
methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration
for practical application of their regulatory effects in oncology was discussed.
l.nefyodov@mail.ruPractical use of amino acids in oncology:
replacement therapy as a structural component
of proteins and/or for correction of metabolism
in quantities comparative with their endogenous
concentrations
Leonid Nefyodov
Yanka Kupala Grodno State University, Belarus
J Org Inorg Chem 2019, Volume:5
DOI: 10.21767/2472-1123-C2-024