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M a y 0 9 - 1 0 , 2 0 1 9
S t o c k h o l m , S w e d e n
Page 44
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Advanced Chemistry 2019
2
nd
European Congress on
Advanced Chemistry
D
irect metal-free C-H functionalization of aromatic and heteroaromatic compounds is a new chapter in organic chemistry. The results
of comprehensive studies on nucleophilic substitution of hydrogen in arenes and hetarenes (the SNH reactions), including their
mechanisms, intermediates, mathematic and electrochemical modeling, kinetics, electron-transfer, etc. will be presented and discussed.
The SNH methodology is of great practical value, since it involves nucleophilic alkylation, alkenylation, alkynylation, arylation, amination,
hydroxylation, alkoxylation, cyanation, cyanomethylation, halogenation, as well as cymantrenylation, carboranylation, ferrocenylation
and other reactions. The SNH reactions change the logic of organic synthesis, providing a powerful synthetic tool to functionalize
C-H chemical bonds in a variety of nitro- and azaaromatic compounds, quinones, azinones, porphyrins, azulenes and arene-metal-
complexes. Also they can be carried out in the electrochemical mode, which opens new opportunities to avoid preliminary incorporation
of good leaving groups or other functionalities in an aromatic ring, thus being in a good agreement with principles of green chemistry.
valery-charushin-562@yandex.ruNucleophilic C-H functionalization of arenes: a
new synthetic tool for green chemistry
Valery N Charushin
1,2
and Oleg N Chupakhin
1,2
1
Postovsky Institute of Organic Synthesis-Ural Branch of RAS, Russia
2
Ural Federal University, Russia
J Org Inorg Chem 2019, Volume:5
DOI: 10.21767/2472-1123-C2-024
H
Nu
+
C
C
H
Oxidant
Nu