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Vascular Surgery 2019
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Page 34
March 28-29, 2019
Rome, Italy
Vascular Surgery
4
th
Edition of World Congress & Exhibition on
Recent Publications
1. Batra R, Suh M K, Carson J S, Dale M A,
Meisinger T M, Fitzgerald M, Opperman P
J, Luo J, Pipinos I I, Xiong W and Baxter B T
(2018) IL-1β (Interleukin-1β) and TNF-α (tumor
necrosis factor-α) impact abdominal aortic
aneurysm formation by differential effects on
macrophage polarization. Arterioscler Thromb
Vasc Biol. 38(2):457-463.
2. DaleMA, XiongW, CarsonJS, SuhMK, Karpisek
A D, Meisinger T M, Casale G P and Baxter B
T (2016) Elastin-derived peptides promote
abdominal aortic aneurysm formation by
modulating M1/M2 macrophage polarization. J
Immunol. 196(11):4536-43.
3. Xiong W, Meisinger T, Knispel R, Worth J M and
Baxter B T (2012) MMP-2 regulates Erk1/2
phosphorylation and aortic dilatation in Marfan
syndrome. Circ Res. 110(12):e92-e101.
4. Xiong W, Mac Taggart J, Knispel R, Worth J,
Persidsky Y and Baxter B T (2009) Blocking
TNF-alpha attenuates aneurysm formation in a
murine model. J Immunol. 183(4):2741-6.
5. XiongW, Longo GM, Greiner TC, Zhao Y, Fiotti N
andBaxterBT(2002)Matrixmetalloproteinases
2 and 9 work in concert to produce aortic
aneurysms. J Clin Invest. 110(5):625-32.
Biography
Wanfen Xiong is an Associate Professor at the University of Nebraska
Medical Center. She received her PhD in Biochemistry and Molecular
Biology. Since she completed her Postdoctoral training at Stanford
University in 1999, she has worked to understand the etiology and
mechanisms of aortic aneurysms. Through the study of a murine Mar-
fan syndrome (MFS) model, she has shown that smooth muscle cells
(SMCs) switched prematurely to a more mature contractile phenotype
at postnatal day 7 in MFS mice. Her research interests are to under-
stand the molecular mechanisms underlying early aneurysm develop-
ment in Marfan syndrome and develop effective strategies to prevent
aneurysm formation.
wxiong@unmc.edu