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May 24-25, 2018
London, UK
Vascular Surgery 2018
3
rd
Edition of World Congress & Exhibition on
Vascular Surgery
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Statement of the Problem:
More than 200 million patients
have periphery artery disease (PAD) worldwide and the number
of asymptomatic PAD patients were several times larger
than that in the symptomatic PAD patients. Without obvious
clinical symptoms, asymptomatic PAD have the similar risk of
cardiovascular mortality and the mortality is much higher than
the health. Though the asymptomatic PAD was observed with
high morbidity and great hazard, sufficient attention has not
been paid. We aimed to systematically appraise the guidelines
on the screening and treatment of asymptomatic PAD and find
out the agreements and the different in the recommendations.
Methodology & Theoretical Orientation:
Clinical guidelines
and consensus statements in English to November 2017 were
searched using MEDLINE, EMBASE and some websites of
guideline organizations. Three reviewers appraised the quality
of the included guidelines by using AGREE II instrument. The
recommendations were also fully extracted and compared.
Findings:
Of 3245 citations identified, 14 guidelines were
included. The AGREE score ranged from 35％ to 75％ , mainly due
to poor quality in “rigour of development” domain and “. Editorial
Independence” domain. For screening, 10 guidelines contained
the recommendations, among which, 8 supported, one opposed
and one guidelines considered insufficient evidence. For the
treatment, most area was blank and the controversy was in
the use of antiplatelet therapy. The guidelines with financial
relationships with pharmaceutical industry or without clear
statement for conflicts of interest, seemed to bemore aggressive
in the screening or treatment.
Conclusion & Significance:
The quality of most guidelines for
the management of asymptomatic PAD should be improved.
More clinical studies with high quality are needed to provide
the clear-cut evidence to answer the controversy and the clear
statement for conflicts of interest should be provided.
Recent Publications
1. Kai H, Xixia L, Miaoyun L, et al. Intraoperative nerve
monitoring reduces recurrent laryngeal nerve injury in
geriatric patients undergoing thyroid surgery[J]. Acta
oto-laryngologica, 2017, 137(12): 1275-1280.
2. Huang K, Luo D, Huang M, et al. Protection of parathyroid
function using carbon nanoparticles during thyroid
surgery[J]. Otolaryngology--Head and Neck Surgery,
2013, 149(6): 845-850.
3. Tang Y, Chen J, Huang K, et al. The incidence, risk factors
and in-hospital mortality of acute kidney injury in patients
after abdominal aortic aneurysm repair surgery[J]. BMC
nephrology, 2017, 18(1): 184.
4. Luo D, Chen H, Lu P, et al. CHI3L1 overexpression is
associated with metastasis and is an indicator of poor
prognosis in papillary thyroid carcinoma[J]. Cancer
Biomarkers, 2017, 18(3): 273-284.
5. Jiang Y, Wang M, Huang K, et al. Oxidized low-density
lipoprotein induces secretion of interleukin-1β by
macrophages via reactive oxygen species-dependent
NLRP3 inflammasome activation[J]. Biochemical and
biophysical research communications, 2012, 425(2):
121-126
Biography
Huang Kai is the expert in the surgery of peripheral vascular surgery and thy-
roid surgery. Chen Qinchang, Male, born in January 1995, student of Dr Huang
Kai, has been studying in Clinical Medicine Major of Zhongshan School of
Medicine in Sun Yat-sen University from August 2013. Without any unexpect-
ed accident, he will be awarded the bachelor’s Degree in medicine. Though he
is the undergraduate at Grade 5, he has been the expert at data mining, gene
chip analysis and clinical research
huangk37@mail.sysu.edu.cnCritical Appraisal of International Guidelines for the Screening
and Treatment of Asymptomatic Periphery Artery Disease: who
decides the non-evidence corner
Qinchang Chen
1
and
Huang Kai
2
1
Sun Yat-sen University, China
2
Sun Yat-Sen Memorial Hospital, China
Qinchang Chen et al., J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-002