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Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
May 24-25, 2018
London, UK
Vascular Surgery 2018
Page 57
3 rd Edition of World Congress & Exhibition on
Vascular Surgery
The role of neutrophils in abdominal aortic
aneurysms
Christoph Neumayer
Medical University Vienna, Austria
Christoph Neumayer, J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-001
Neutrophil extracellular cells have emerged to bemore important
in their role of inflammatory responses than phagocytic actions.
Recent publications showed neutrophils to be involved in the
activation of the IL-1 family and subsequent distribution of
neutrophil proteases to the inflammatory site. The abdominal
aortic aneurysm (AAA) is considered a chronic inflammatory
disease with neutrophils recruited to the aneurysm site and
intraluminal thombus, releasing neutrophil proteases and
reactive oxygen species, which contribute to media destruction.
D-Dimer and myeloperoxidase, distinctive neutrophil proteases
have evolved as potential sensitive AAAmarkers, supporting the
hypothesis of neutrophils to be key players in AAA pathogenesis.
During the recruitment of neutrophils to the aneurysm site and
intraluminal thrombus, activated neutrophils may undergo
the process of NETosis, which involves histone modification
by citrullination, allowing the DNA to be condensated and
subsequent DNA and sticky traps release into the extracellular
space. These NETs are recently discussed to be a potential
biomarker in AAA pathogenesis. NETs were found in AAA
mouse model and its inhibition prevented AAA development.
Furthermore, anti-inflammatory treatment such as metformin
in diabetic patients was associated with reduced AAA growth.
The potential therapeutic approach of metformin in systemic
lupus erythematodous could already be elucidated by reduced
inflammatory skin flares through reduced NET formation.
In summary, neutrophils, neutrophil proteases and NETs are
intensively discussed as potential biomarkers in AAA, this
lecture will give an overview of all recent findings on neutrophils
and their products in AAA.
Recent Publications
1. Piechota-Polanczyk A, Jozkowicz A, Nowak W, Eilenberg
W, Neumayer C, Malinski T, Huk I and Brostjan C (2015):
The abdominal aortic aneurysm and intraluminal
thrombus: current concepts of development and
treatment(review). 2015 Front. Cardiovasc. Med. 2015
Volume 2 Article 19
2. W.Eilenberg,S.Stojkovic,A.Piechota-Polanczyk,C.Kaun,
S. Rauscher, M. Gröger, M. Klinger, J. Wojta, C. Neumayer,
I. Huk, S. Demyanets. Neutrophil Gelatinase-Associated
Lipocalin (NGAL) is associatedwith symptomatic carotid
atherosclerosis and drives pro-inflammatory state in
vitro Eur J Vasc Endovasc Surg (2016) 51(5):623-31
3. W. Eilenberg, S. Stojkovic, A. Kaider, N. Kozakowski,
C.M. Domenig, C. Burghuber, J. Nanobachvili, K. Huber,
C. Neumayer, I. Huk, J. Wojta, S. Demyanets. NGAL and
MMP-9/NGAL as biomarkers of plaque vulnerability and
targets of statins in patients with carotid atherosclerosis.
Clinical Chemistry and LaboratoryMedicine. (2017) June
4. W. Eilenberg, S. Stojkovic, A. Piechota-Polanczyk, A.
Kaider, N. Kozakowski, W. Weninger, J. Nanobachvili, J.
Wojta, I. Huk, S. Demyanets, C. Neumayer. Neutrophil
Gelatinase Associated Lipocalin (NGAL) is elevated in
type 2 diabetics with carotid artery stenosis and reduced
under metformin treatment. Cardiovascular Diabetology
(2017) 16:98
5. Jabłońska A, Neumayer C, Bolliger M, Gollackner B,
Klinger M, Paradowska E, Nanobachvili J, Huk I. Analysis
of host Toll-like receptor 3 and RIG-I-like receptor gene
expression in patients with abdominal aortic aneurysm.
J Vasc Surg. 2018 Mar 19. S0741-5214(17)32687-3.
Biography
Prof. Christoph Neumayer is the interim head of the division of Vascular
Surgery, Department of Surgery, Medical University Vienna. His main re-
search focus inherits carotid atherosclerosis and the abdominal aortic an-
eurysm, especially basic researchmodels of AAA inmice and novel therapy
options.