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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
E u r o p e a n C o n g r e s s o n
Vaccines & Vaccination
and Gynecologic Oncology
Vaccines & Vaccination and Gynecologic Oncology 2018
O c t o b e r 2 6 - 2 7 , 2 0 1 8
B u d a p e s t , H u n g a r y
Vaccine strain selection for FMD serotype O viruses in
Southeast Asia and East Asia using antigenic and genetic data
by measuring the effect of protective viral determinants
Sasmita Upadhyaya
The Pirbright Institute, UK
Jenner Institute (NDM), University of Oxford, UK
Boehringer Ingelheim (BI), the Netherlands
Sasmita Upadhyaya, Journal of Clinical Immunology and Allergy, Volume: 4
DOI: 10.21767/2471-304X-C2-005
F
oot and mouth disease (FMD), caused by FMD virus (FMDV) is a highly
contagious disease affecting cloven hoofed animals. Although vaccination
is one of the most important control measures to prevent FMD outbreaks, the
available vaccines may not provide enough cross protection against recent
circulating FMDV, mainly due to emergence of new lineages and sub lineages.
Therefore, the main aim of this project is to find out a suitable cross protecting
vaccine strain by matching (antigenic and genetic characterisation) circulating
viruses with existing vaccines and new putative vaccine strains. So in the first
year of this study, a total of 50 serotype O (2013-2017) viruses selected from SEA,
Far East and EA countries, were characterised by virus neutralisation test and
capsid sequencing. O/PanASIA-2 is seen to be the broad cross reacting vaccine
for serotype O. However, recent circulating CATHAY topotype viruses are not
protected by any of these existing vaccines. Further capsid sequence analysis
of these viruses elucidated amino acid changes in the antigenic sites of these
viruses. The effect of these amino acids changes are being investigated using
reverse genetics technique. This can help to design new vaccines, which can give
better cross protection against the circulating viruses.
Euro Vaccines 2018
Biography
She is currently studying in The Pirbright Institute, UK.
sasmita.upadhyaya@pirbrigh.ac.uk