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Journal of Preventive Medicine
ISSN: 2572-5483
July 16-17, 2018
London, UK
Preventive Medicine 2018
Page 35
9th Edition of International Conference on
Preventive Medicine
& Public Health
Hydrogengasproducedbyintestinalfermentationissuggested
to have some preventive effects on age-related diseases. As
reported in our previous paper, hydrogen gas concentrations in
the breath, reflecting the intestinal production, were measured
in 14 healthy controls (8 men, 6 women; 37.3 (17.4) years) and
15 elderly people with type 2 diabetes (4 men, 11 women; 79 (6)
years) 26 centenarians (6 men, 20 women; age, 102 (2) years
(mean (SD)) and16 their offspring (7men, 9women; 70 (5) years),
and were found to be significantly increased in centenarians. In
that study, diabetic patients treated with α-glucosidase inhibitors
were excluded, which can cause carbohydrate malabsorption
leading to increasing intestinal fermentation. In the current
study, 28 diabetic patients (11 men, 17 women; 69 (13) years)
including 6 patients treated with α-glucosidase inhibitors were
studied. Three patients treated with α-glucosidase inhibitors
showed extremely high concentrations of breath hydrogen gas,
which were compatible to those in a part of centenarians, and
low concentrations of serum oxidative low-density lipoprotein
(MDA-LDL). No significant correlation was found between
breath hydrogen gas and serumMDA-LDL concentrations. Thus,
hydrogen gas produced by intestinal fermentation in association
with diet and gut microbiome may affect people’s longevity in
Japan, considering the potential of hydrogen gas to act as a
potent antioxidant in the body.
Biography
Dr. Yuji Aoki is the Director of the Outpatient Department, and head of the Life-
style Disease Laboratory, National Hospital Organization Matsumoto Medical
Center, Matsumoto, Japan. He is a Visiting Clinical Professor of Internal Medi-
cine, Matsumoto Dental University Hospital, Shiojiri, Japan. He got his Medical
Doctor in 1981 and Ph.D.-medicine in 1993 at Shinshu University School of
Medicine, Matsumoto, Japan.
Education:
1993 Ph.D. at Shinshu University School of Medicine, Japan
1981 MD at Shinshu University School of Medicine, Japan
Research Fellow:
1995 Division of Nephrology, Georgetown University Medical Center, 1993-
Washington, D.C., U.S.A.
Award:
1995 The Mamie Doud Eisenhower Memorial Fellowship Award, American
Heart Association, Washington, D.C., USA.
Yuji Aoki
National Hospital Organization Matsumoto Medical Center, Japan
Yuji Aoki, J Prev Med 2018, Volume 3
DOI: 10.21767/2572-5483-C1-001
Increased concentrations of breath hydrogen
gas originated from intestinal bacteria may be
related to people’s longevity in Japan